MedDataX Logo

Assessment of Endothelial and Haemostatic Changes During Severe SARS-CoV-2 Infection

NCT ID: NCT04357847

Last Updated: 2021-04-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-04-09

Study Completion Date

2021-08-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The outbreak at covid-19 is caused by the SARS-CoV-2 virus. This virus can be responsible for severe respiratory failure but also for extra-respiratory organ dysfunctions associated with severe inflammatory stress. The endothelium is an important structure of the blood vessels and is implicated in the organ failure of many patients admitted in intensive care units. It could be affected by the virus and its alteration may explain the organ dysfunction of covid-19 ICU patients as well as the thrombotic processes frequently obstructed in this infection.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

MIcrovascular Dysfunction in CRitically Ill cOVID-19 Patients

NCT04819802

Covid-19 Critical Illness Hemodynamics +1 more
UNKNOWN

ProAdrenomedullin Assessment of Multi-Organ Failure in COvid-19 Sepsis

NCT04522310

Covid19
COMPLETED

Endothelial Function, Inflammation and Organ Dysfunction in COVID-19

NCT04408365

COVID Shock
UNKNOWN

Pro-thrombotic Status in Patients with SARS-Cov-2 Infection

NCT04343053

Severe Acute Respiratory Syndrome Coronavirus 2
COMPLETED NA

Predictive Biomarkers of Secondary Aggravation in Covid-19 Suspect Patient

NCT04341792

Infection Viral Coronavirus COVID-19
COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Covid-19 Endothelial Dysfunction Thrombosis Critically Ill

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* all adult patients admitted in ICU for covid-19 disease within the past 24 hrs

Exclusion Criteria

* bactrial co-infection at admission
* expected death within the next 24 hrs
* pregnancy
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

University Hospital, Rouen

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

EBESNIER

Principal investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Rouen University Hospital

Rouen, , France

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

France

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

emmanuel besnier, MD

Role: CONTACT

[email protected]
+33 2 32 88 82 83

thomas clavier, MD, PhD

Role: CONTACT

[email protected]
+33 2 32 88 82 83

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

emmanuel besnier, MD

Role: primary

[email protected]
+33 2 32 88 82 83

thomas clavier, MD, PhD

Role: backup

[email protected]
+33 2 32 88 82 83

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

2020/097/OB

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Acute Encephalopathy in Critically Ill Patients With COVID-19
NCT04320472 UNKNOWN
A Study to Learn About the Occurrence of Disseminated Intravascular Coagulation in People With Sepsis and Further Worsening of Sepsis
NCT06986798 ACTIVE_NOT_RECRUITING NA
Anticoagulation in Patients Suffering From COVID-19 Disease The ANTI-CO Trial
NCT04445935 UNKNOWN PHASE4
Effects of Norepinephrine and Volume Expansion in Capillary Refill Time in Septic Shock
NCT04870892 UNKNOWN
Study of the Impact of Changes in Carbonemia on Microcirculation in Patients Achieving a Test Hypercapnia
NCT02549378 COMPLETED NA
The Impact of Coagulation Disorders on the Diagnosis and Prognosis of Sepsis
NCT05998733 UNKNOWN
Proadrenomedullin and Microcirculation in Monitoring Organ Dysfunction in Patient With Infection
NCT03931967 COMPLETED
Evaluation of the Prognostic Value of Immature Platelet Fraction
NCT07039227 ACTIVE_NOT_RECRUITING
Endothelium in Severe Sepsis
NCT00793442 COMPLETED
Study of the Role of Interferon αon the Endothelial Dysfunction During Septic Shock
NCT04204694 UNKNOWN
Study of Coagulation Profile and Role of Heparin Like Effect in Patients With COVID-19
NCT04668404 UNKNOWN
Analysis of Sublingual Glycocalyx Damage at ICU Admission to Predict Risk of Death
NCT03847493 UNKNOWN
MR-Evaluation of Renal Function In Septic Patients
NCT02765191 COMPLETED NA
Circulatory Coherence in COVID-19 and Non-COVID-19 Patients With Sepsis
NCT04644302 COMPLETED
COVID-19 : Study of INFLAmmasome and PLAtelets Functions
NCT04397822 COMPLETED
Effects of Acute Systemic Inflammation on Arterial Stiffness and Microcirculation.
NCT01556373 COMPLETED
Establishment of Early Diagnosis and Monitoring Model for Sepsis Patients
NCT04974411 UNKNOWN
Sidestream Dark-Field (SDF) Imaging of the Intestinal Microcirculation
NCT00883597 COMPLETED
Correlation Between PTP1B Expression and Organ Failure During Sepsis
NCT02295514 COMPLETED NA
The Early Coagulopathy for the Prognosis in Sepsis
NCT04582188 UNKNOWN
Efficacy and Safety of Angiotensin II Use in Coronavirus Disease(COVID)-19 Patients With Acute Respiratory Distress Syndrome
NCT04408326 UNKNOWN
Validation of COVILUS Score in Patients Suspected of COVID-19 Infection in the Emergency Room
NCT04666064 COMPLETED
Identification of Markers of Poor Clinical Prognosis in Sepsis by Epigenetic Analysis
NCT06446947 RECRUITING
Polyvalent Immunoglobulin in COVID-19 Related ARds
NCT04350580 COMPLETED PHASE3
Cardiac Stress in Septic Shock - Biomarkers, Echocardiography and Outcome
NCT01747187 UNKNOWN