MedDataX Logo

Analysis of Sublingual Glycocalyx Damage at ICU Admission to Predict Risk of Death

NCT ID: NCT03847493

Last Updated: 2022-11-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-04-15

Study Completion Date

2023-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The aim of this observative, prospective study is to evaluate if and to what extent glycocalyx damage/microcirculation data at admission in the ICU as well as during ICU stay can be predictive of mortality and clinical course in patients presenting with the suspicion of sepsis/septic shock. Therefore, the enrollment of ca 100 ICU patients is planned.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Early Detection of Glycocalyx Damage in Emergency Room Patients

NCT03126032

Sepsis SIRS
COMPLETED

Glycocalyx and Microcirculation in Sepsis

NCT03960307

Sepsis
COMPLETED

Vaccine Response in Patient With Sepsis

NCT04823039

Sepsis
COMPLETED NA

Usage of Glucose Fluctuations as a Prognostic Marker in Septic Shock Patients

NCT07234526

Glucose Fluctuations in Sepsis
NOT_YET_RECRUITING

Evaluation of New Hemodynamic Indices

NCT03961594

Septic Shock
UNKNOWN NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Sepsis Septic Shock Endothelial Dysfunction

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Patients with suspected sepsis

Patients admitted in the ICU with the clinical suspicion of infection/sepsis.

Endothelial Glycocalyx

Intervention Type OTHER

Non-invasive assessment of endothelial glycocalyx dimensions.

Non-sepsis Patients (control group)

Patients admitted in the ICU with other conditions apart from infection/sepsis.

Endothelial Glycocalyx

Intervention Type OTHER

Non-invasive assessment of endothelial glycocalyx dimensions.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Endothelial Glycocalyx

Non-invasive assessment of endothelial glycocalyx dimensions.

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* ICU patients admitted to the ICU with the clinican suspicion of sepsis/septic shock.

Exclusion Criteria

* Underage persons, pregnant women, patients with inflammation or trauma of sublingual mucosa.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

University Hospital Muenster

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Philipp Kümpers, MD

Role: PRINCIPAL_INVESTIGATOR

University Hospital Muenster

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Universitiy Hospital Muenster

Münster, , Germany

Site Status

Countries

Review the countries where the study has at least one active or historical site.

Germany

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

ASGARD

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

The Effect of Nitroglycerine on Microcirculatory Abnormalities During Sepsis
NCT00493415 COMPLETED PHASE3
Prospective Validation of Clini-biological Parameters Including Initial Hemostasis, Which Improve the Prediction of Death at 1 Month Among Patients With Septic Shock
NCT01231672 COMPLETED
Molecular Biomarkers for Sepsis
NCT04280354 TERMINATED
Endothelium in Severe Sepsis
NCT00793442 COMPLETED
Cardiac Stress in Septic Shock - Biomarkers, Echocardiography and Outcome
NCT01747187 UNKNOWN
Septic Shock-induced Immunosuppression
NCT04067674 RECRUITING
Sepsis Early EvaluatioN Through Rapid Ultrasound and veNous Gas Analysis
NCT05787184 UNKNOWN
Assessment of Endothelial and Haemostatic Changes During Severe SARS-CoV-2 Infection
NCT04357847 UNKNOWN
Influence of In-line Microfilters on Systemic Inflammation in Adult Critically Ill Patients
NCT01534390 COMPLETED PHASE2
Correlation of VEGF-A and Fluid Balance in Septic Shock
NCT04474431 UNKNOWN NA
Predict Sepsis; the Predictive Value of Bedside Measures in the Ambulance
NCT03249597 COMPLETED
The Relation Between Triglyceride- Glucose Index, Procalcitonin and Cardiac Affection in Septic Shock.
NCT06518083 NOT_YET_RECRUITING
Value of Laboratory Biomarkers in Prediction of Outcome in Septic Patients
NCT06338124 RECRUITING
Comparison of Sepsis Prediction Algorithms
NCT05943938 NOT_YET_RECRUITING
A Prospective Observational Study of Sepsis
NCT05309889 UNKNOWN
Mitochondrial Function in Septic Patients
NCT03748537 COMPLETED NA
Effects of Norepinephrine and Volume Expansion in Capillary Refill Time in Septic Shock
NCT04870892 UNKNOWN
Emergency Echocardiography in Sepsis
NCT04580888 COMPLETED NA
German Lactat Clearance in Severe Sepsis
NCT01929772 COMPLETED
(1,3)-β-D-glucan Based Diagnosis of Invasive Candida Infection in Sepsis
NCT02734550 COMPLETED NA
Rotational Thromboelastometry Versus DIC Score in Sepsis
NCT04610853 COMPLETED
Mortality of Sepsis in Swedish Intensive Care Units 2008-2016
NCT03489447 COMPLETED
The Distribution of Plasma Drug Concentrations of Beta-lactam Antibiotics in Intensive Care Unit Patients
NCT02446392 COMPLETED
A Study to Learn About the Occurrence of Disseminated Intravascular Coagulation in People With Sepsis and Further Worsening of Sepsis
NCT06986798 ACTIVE_NOT_RECRUITING NA
Evaluation of Parameters Collected From Routine Data for the Diagnosis of Sepsis and Septic Shock and Their Influence on Time to Diagnosis and Patient Outcome
NCT05383963 RECRUITING