Predictive Biomarkers of Secondary Aggravation in Covid-19 Suspect Patient

NCT ID: NCT04341792

Last Updated: 2025-12-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

373 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-04-11

Study Completion Date

2020-11-12

Brief Summary

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There is no predictive tool for patients admitted to the emergency department with a suspicion of Covid-19 that will worsen secondarily and require a heavy lifting.

In a context of saturation of the healthcare system by the pandemic at Covid-19,it is essential to identify specific, accessible prognostic markers via minimally invasive sampling with low risk of infection for personnel caregiver, for optimal allocation of resuscitation resources.

This study proposes to evaluate the biological markers of routine care known to be associated with resuscitation admission in relation to hospitalization on conventional service for the prediction of worsening of patients admitted to the emergencies for Covid-19.

Detailed Description

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Conditions

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Infection Viral Coronavirus COVID-19

Keywords

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infection viral biological risk factor coronavirus covid-19

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Clinical criteria for suspicion of Covid-19 in an epidemic period
* Consultation in the emergency departement
* Non-opposition agree

Exclusion Criteria

* impairment related to another identified cause than Covid-19, in particular a rapid diagnostic test flu-positive
* Severe patient from the outset with transfer to intensive care within 12 hours of admission to the Emergency Department
* No social security coverage (beneficiary or entitled person)
* Poor understanding of French
* Refusal to participate
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Lille

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Delphine Garrigue, MD

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Lille

Locations

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Hôpital Roger Salengro, CHU Lille

Lille, , France

Site Status

Countries

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France

References

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Ledoult E, Guerrier T, Dubucquoi S, Figeac M, Villenet C, Daunou B, Behal H, Pokeerbux MR, Machet T, Koether V, Collet A, Launay D; Lille Covid Research network (LICORNE). Dual role of plasmablasts as immune regulators or amplifiers in COVID-19. Clin Immunol. 2025 Oct 13;281:110609. doi: 10.1016/j.clim.2025.110609. Online ahead of print.

Reference Type DERIVED
PMID: 41093046 (View on PubMed)

Other Identifiers

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2020-A00906-33

Identifier Type: OTHER

Identifier Source: secondary_id

2020_33

Identifier Type: -

Identifier Source: org_study_id