Quantification of the Visual Benefits of Soft Toric Contact Lenses Compared to Soft Spherical Contact Lenses

NCT ID: NCT04613882

Last Updated: 2023-10-11

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

59 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-09-28

Study Completion Date

2022-06-21

Brief Summary

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The aim of this work is to undertake a range of vision-related measures with soft toric contact lenses soft spherical contact lenses and spectacle lens correction across a range of levels of astigmatism.

Detailed Description

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This will be a randomised, crossover, partially subject-masked (for contact lenses only), non-dispensing study, controlled by cross-comparison.

Conditions

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Astigmatism

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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Soft Toric Custom Made contact lenses

Subjects will be randomized to wear Soft Toric custom made contact lenses for 30 minutes in one eye with other eye patched.

Group Type EXPERIMENTAL

Soft Toric Custom Made Contact lens

Intervention Type DEVICE

Subjects will be randomized to wear soft toric custom made lenses for 30 minutes in one eye with other eye patched.

Soft Spherical Contact Lenses

Intervention Type DEVICE

Subjects will be randomized to wear soft spherical contact lenses for 30 minutes in one eye with other eye patched.

Spectacle Correction

Intervention Type DEVICE

Subjects will be randomized to wear spectacle Correction for 30 minutes in one eye with other eye patched.

Soft Spherical Contact Lenses

Subjects will be randomized to wear soft spherical contact lens for 30 minutes in one eye with other eye patched

Group Type ACTIVE_COMPARATOR

Soft Toric Custom Made Contact lens

Intervention Type DEVICE

Subjects will be randomized to wear soft toric custom made lenses for 30 minutes in one eye with other eye patched.

Soft Spherical Contact Lenses

Intervention Type DEVICE

Subjects will be randomized to wear soft spherical contact lenses for 30 minutes in one eye with other eye patched.

Spectacle Correction

Intervention Type DEVICE

Subjects will be randomized to wear spectacle Correction for 30 minutes in one eye with other eye patched.

Spectacle Correction

Subjects will be randomized to wear spectacle Correction for 30 minutes in one eye with other eye patched.

Group Type ACTIVE_COMPARATOR

Soft Toric Custom Made Contact lens

Intervention Type DEVICE

Subjects will be randomized to wear soft toric custom made lenses for 30 minutes in one eye with other eye patched.

Soft Spherical Contact Lenses

Intervention Type DEVICE

Subjects will be randomized to wear soft spherical contact lenses for 30 minutes in one eye with other eye patched.

Spectacle Correction

Intervention Type DEVICE

Subjects will be randomized to wear spectacle Correction for 30 minutes in one eye with other eye patched.

Interventions

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Soft Toric Custom Made Contact lens

Subjects will be randomized to wear soft toric custom made lenses for 30 minutes in one eye with other eye patched.

Intervention Type DEVICE

Soft Spherical Contact Lenses

Subjects will be randomized to wear soft spherical contact lenses for 30 minutes in one eye with other eye patched.

Intervention Type DEVICE

Spectacle Correction

Subjects will be randomized to wear spectacle Correction for 30 minutes in one eye with other eye patched.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

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Subjects will only be eligible for the study if:

1. They are of legal age between 18 and 40 years.
2. They understand their rights as a research subject and are willing and able to sign a Statement of Informed Consent.
3. They are willing and able to follow the protocol.
4. They are current wearers of any soft contact lens (i.e. have worn lenses in the last six months).
5. They have refractive ocular astigmatism between 0.00DC and -1.50DC in one or both eyes.
6. They have a spherical component to their ocular refractive error between 0.00 and - 6.00 DS.
7. They could attain at least 0.10 logMAR distance high contrast visual acuity in one eye with the study lenses within the available power range.
8. They can be fitted satisfactorily with both lens types.
9. They own an acceptable pair of spectacles.
10. They agree not to participate in other clinical research for the duration of this study.

Exclusion Criteria

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Subjects will not be eligible to take part in the study if:

1. They have an ocular disorder which would normally contra-indicate contact lens wear.
2. They have a systemic disorder which would normally contra-indicate contact lens wear.
3. They are using any topical medication such as eye drops or ointment.
4. They have had corneal refractive surgery.
5. They have any corneal distortion resulting from previous hard or rigid lens wear or have keratoconus.
6. They are pregnant or breastfeeding.
7. They have any ocular abnormality which would, in the opinion of the investigator, normally contraindicate contact lens wear.
8. They have an amblyopic eye, in which case only dominant eye will be assessed for that subject.
9. They have an infectious disease (e.g. hepatitis), any immunosuppressive disease (e.g. HIV) or diabetes.
10. They have a history of severe allergic reaction or anaphylaxis.
11. They have taken part in any other contact lens clinical trial or research, within two weeks prior to starting this study.
Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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CooperVision, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Michael Read

Role: PRINCIPAL_INVESTIGATOR

Eurolens Research

Locations

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Eurolens Research

Manchester, , United Kingdom

Site Status

Countries

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United Kingdom

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

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C19-683 (EX-MKTG-116)

Identifier Type: -

Identifier Source: org_study_id

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