Trial Outcomes & Findings for Quantification of the Visual Benefits of Soft Toric Contact Lenses Compared to Soft Spherical Contact Lenses (NCT NCT04613882)

NCT ID: NCT04613882

Last Updated: 2023-10-11

Results Overview

Visual acuity was assessed using logMAR for each intervention.

Recruitment status

COMPLETED

Study phase

NA

Target enrollment

59 participants

Primary outcome timeframe

Baseline with low contrast VA

Results posted on

2023-10-11

Participant Flow

59 participants were screened for eligibility. Two participants did not meet the inclusion criteria and therefore were not included in the randomization. Each of the 3 interventions were subdivided into 7 cylinder groups based on required astigmatism range. Of the remaining 57 participants, 4 participants were assigned to cylinder groups which were already full and thus they did not receive any of the interventions. The remaining 53 participants completed the study using the three interventions.

Unit of analysis: Eyes

Participant milestones

Participant milestones
Measure
Spherical Contact Lens, Spectacle, Toric Contact Lens
Spherical CL for 30 minutes, then Spectacles for 30 minutes, then Toric CL for 30 minutes
Spherical Contact Lens, Toric Contact Lens, Spectacle
Spherical CL for 30 minutes, then Toric CL for 30 minutes, then Spectacles for 30 minutes
Spectacle, Spherical Contact Lens, Toric Contact Lens
Spectacles for 30 minutes, then Spherical CL for 30 minutes, then Toric CL for 30 minutes
Spectacles, Toric Contact Lens, Spherical Contact Lens
Spectacles for 30 minutes, then Toric CL for 30 minutes, then Spherical CL for 30 minutes
Toric Contact Lens, Spherical Contact Lens, Spectacles
Toric CL for 30 minutes, then Spherical CL for 30 minutes, then Spectacles for 30 minutes
Toric Contact Lens, Spectacles, Spherical Contact Lens
Toric CL for 30 minutes, then Spectacles for 30 minutes, then Spherical CL for 30 minutes
First Intervention
STARTED
14 23
6 9
9 15
5 6
6 9
13 22
First Intervention
COMPLETED
14 23
6 9
9 15
5 6
6 9
13 22
First Intervention
NOT COMPLETED
0 0
0 0
0 0
0 0
0 0
0 0
Second Intervention
STARTED
14 23
6 9
9 15
5 6
6 9
13 22
Second Intervention
COMPLETED
14 23
6 9
9 15
5 6
6 9
13 22
Second Intervention
NOT COMPLETED
0 0
0 0
0 0
0 0
0 0
0 0
Third Intervention
STARTED
14 23
6 9
9 15
5 6
6 9
13 22
Third Intervention
COMPLETED
14 23
6 9
9 15
5 6
6 9
13 22
Third Intervention
NOT COMPLETED
0 0
0 0
0 0
0 0
0 0
0 0

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

Race and Ethnicity were not collected from any participant.

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure
Spherical Contact Lens, Spectacles, Toric Contact Lens
n=23 Eyes
Spherical CL for 30 minutes, then Spectacles for 30 minutes, then Toric CL for 30 minutes
Spherical Contact Lens, Toric Contact Lens, Spectacles
n=9 Eyes
Spherical CL for 30 minutes, then Toric CL for 30 minutes, then Spectacles for 30 minutes
Spectacles, Spherical Contact Lens, Toric Contact Lens
n=15 Eyes
Spectacles for 30 minutes, then Spherical CL for 30 minutes, then Toric CL for 30 minutes
Spectacles, Toric Contact Lens, Spherical Contact Lens
n=6 Eyes
Spectacles for 30 minutes, then Toric CL for 30 minutes, then Spherical CL for 30 minutes
Toric Contact Lens, Spherical Contact Lens, Spectacles
n=9 Eyes
Toric CL for 30 minutes, then Spherical CL for 30 minutes, then Spectacles for 30 minutes
Toric Contact Lens, Spectacles, Spherical Contact Lens
n=22 Eyes
Toric CL for 30 minutes, then Spectacles for 30 minutes, then Spherical CL for 30 minutes
Total
n=84 Eyes
Total of all reporting groups
Age, Continuous
26.1 years
STANDARD_DEVIATION 4.8 • n=23 Eyes
27.3 years
STANDARD_DEVIATION 5.6 • n=9 Eyes
25.9 years
STANDARD_DEVIATION 5.0 • n=15 Eyes
28.2 years
STANDARD_DEVIATION 7.7 • n=6 Eyes
25.4 years
STANDARD_DEVIATION 6.7 • n=9 Eyes
27.8 years
STANDARD_DEVIATION 6.3 • n=22 Eyes
26.5 years
STANDARD_DEVIATION 5.7 • n=84 Eyes
Sex: Female, Male
Female
14 Eyes
n=23 Eyes
5 Eyes
n=9 Eyes
13 Eyes
n=15 Eyes
6 Eyes
n=6 Eyes
3 Eyes
n=9 Eyes
17 Eyes
n=22 Eyes
58 Eyes
n=84 Eyes
Sex: Female, Male
Male
9 Eyes
n=23 Eyes
4 Eyes
n=9 Eyes
2 Eyes
n=15 Eyes
0 Eyes
n=6 Eyes
6 Eyes
n=9 Eyes
5 Eyes
n=22 Eyes
26 Eyes
n=84 Eyes
Race and Ethnicity Not Collected
0 Participants
Race and Ethnicity were not collected from any participant.

PRIMARY outcome

Timeframe: Baseline with low contrast VA

Visual acuity was assessed using logMAR for each intervention.

Outcome measures

Outcome measures
Measure
Overall Participants
n=84 Eyes
Total participants who completed the study
Soft Toric Custom Made Contact Lenses
Participants wore a spherical contact lens, a custom-made toric contact lens, and a spectacle correction, each in a random sequence for 30 minutes. Each optical correction was worn in one eye only, with the other eye patched. Participants had either a single eye or both eyes evaluated.
Spectacle Correction
Participants wore a spherical contact lens, a custom-made toric contact lens, and a spectacle correction, each in a random sequence for 30 minutes. Each optical correction was worn in one eye only, with the other eye patched. Participants had either a single eye or both eyes evaluated.
Visual Acuity
0.2 logMAR
Standard Deviation 0.09

PRIMARY outcome

Timeframe: After 30 minutes of dispense (Low Contrast VA)

Visual acuity was assessed using logMAR for each intervention.

Outcome measures

Outcome measures
Measure
Overall Participants
n=84 Eyes
Total participants who completed the study
Soft Toric Custom Made Contact Lenses
n=84 Eyes
Participants wore a spherical contact lens, a custom-made toric contact lens, and a spectacle correction, each in a random sequence for 30 minutes. Each optical correction was worn in one eye only, with the other eye patched. Participants had either a single eye or both eyes evaluated.
Spectacle Correction
n=84 Eyes
Participants wore a spherical contact lens, a custom-made toric contact lens, and a spectacle correction, each in a random sequence for 30 minutes. Each optical correction was worn in one eye only, with the other eye patched. Participants had either a single eye or both eyes evaluated.
Visual Acuity
0.28 logMAR
Standard Deviation 0.013
0.24 logMAR
Standard Deviation 0.09
0.21 logMAR
Standard Deviation 0.09

PRIMARY outcome

Timeframe: Baseline with High contrast VA

Visual acuity was assessed using logMAR for each intervention.

Outcome measures

Outcome measures
Measure
Overall Participants
n=84 Eyes
Total participants who completed the study
Soft Toric Custom Made Contact Lenses
Participants wore a spherical contact lens, a custom-made toric contact lens, and a spectacle correction, each in a random sequence for 30 minutes. Each optical correction was worn in one eye only, with the other eye patched. Participants had either a single eye or both eyes evaluated.
Spectacle Correction
Participants wore a spherical contact lens, a custom-made toric contact lens, and a spectacle correction, each in a random sequence for 30 minutes. Each optical correction was worn in one eye only, with the other eye patched. Participants had either a single eye or both eyes evaluated.
Visual Acuity
-0.07 logMAR
Standard Deviation 0.07

PRIMARY outcome

Timeframe: After 30 minutes of dispense (High Contrast VA)

Visual acuity was assessed using logMAR for each intervention.

Outcome measures

Outcome measures
Measure
Overall Participants
n=84 Eyes
Total participants who completed the study
Soft Toric Custom Made Contact Lenses
n=84 Eyes
Participants wore a spherical contact lens, a custom-made toric contact lens, and a spectacle correction, each in a random sequence for 30 minutes. Each optical correction was worn in one eye only, with the other eye patched. Participants had either a single eye or both eyes evaluated.
Spectacle Correction
n=84 Eyes
Participants wore a spherical contact lens, a custom-made toric contact lens, and a spectacle correction, each in a random sequence for 30 minutes. Each optical correction was worn in one eye only, with the other eye patched. Participants had either a single eye or both eyes evaluated.
Visual Acuity
-0.02 logMAR
Standard Deviation 0.11
-0.08 logMAR
Standard Deviation 0.07
-0.1 logMAR
Standard Deviation 0.06

SECONDARY outcome

Timeframe: Entrance (Prior to wear of study lens)

Slit lamp Biomicroscopy findings were assessed on Efron Grading scales scored to the nearest 0.1 on a scale of 0 - 4 (0=normal, 1=trace, 2=mild, 3=moderate, 4=severe). The assessments done were recorded prior to the first intervention. Here the time frame used is "Entrance" which refers to the time prior to wear of study lens.

Outcome measures

Outcome measures
Measure
Overall Participants
n=84 Eyes
Total participants who completed the study
Soft Toric Custom Made Contact Lenses
Participants wore a spherical contact lens, a custom-made toric contact lens, and a spectacle correction, each in a random sequence for 30 minutes. Each optical correction was worn in one eye only, with the other eye patched. Participants had either a single eye or both eyes evaluated.
Spectacle Correction
Participants wore a spherical contact lens, a custom-made toric contact lens, and a spectacle correction, each in a random sequence for 30 minutes. Each optical correction was worn in one eye only, with the other eye patched. Participants had either a single eye or both eyes evaluated.
Slit Lamp Biomicroscopy Findings - Conjunctival Redness
1.0 units on a scale
Standard Deviation 0.3

SECONDARY outcome

Timeframe: At Exit (After 30 minutes in each of three interventions)

Slit lamp Biomicroscopy findings were assessed on Efron Grading scales scored to the nearest 0.1 on a scale of 0 - 4 (0=normal, 1=trace, 2=mild, 3=moderate, 4=severe). The assessments were done following the removal of the third intervention. Here the time frame used is "Exit" which refers to those measurements taken post-lens/spectacle wear.

Outcome measures

Outcome measures
Measure
Overall Participants
n=84 Eyes
Total participants who completed the study
Soft Toric Custom Made Contact Lenses
Participants wore a spherical contact lens, a custom-made toric contact lens, and a spectacle correction, each in a random sequence for 30 minutes. Each optical correction was worn in one eye only, with the other eye patched. Participants had either a single eye or both eyes evaluated.
Spectacle Correction
Participants wore a spherical contact lens, a custom-made toric contact lens, and a spectacle correction, each in a random sequence for 30 minutes. Each optical correction was worn in one eye only, with the other eye patched. Participants had either a single eye or both eyes evaluated.
Slit Lamp Biomicroscopy Findings - Conjunctival Redness
1.0 units on a scale
Standard Deviation 0.3

SECONDARY outcome

Timeframe: Entrance (Prior to wear of study lens)

Slit lamp Biomicroscopy findings were assessed on Efron Grading scales scored to the nearest 0.1 on a scale of 0 - 4 (0=normal, 1=trace, 2=mild, 3=moderate, 4=severe). The assessments done were recorded prior to the first intervention. Here the time frame used is "Entrance" which refers to the time prior to wear of study lens.

Outcome measures

Outcome measures
Measure
Overall Participants
n=84 Eyes
Total participants who completed the study
Soft Toric Custom Made Contact Lenses
Participants wore a spherical contact lens, a custom-made toric contact lens, and a spectacle correction, each in a random sequence for 30 minutes. Each optical correction was worn in one eye only, with the other eye patched. Participants had either a single eye or both eyes evaluated.
Spectacle Correction
Participants wore a spherical contact lens, a custom-made toric contact lens, and a spectacle correction, each in a random sequence for 30 minutes. Each optical correction was worn in one eye only, with the other eye patched. Participants had either a single eye or both eyes evaluated.
Slit Lamp Biomicroscopy Findings - Limbal Redness
0.9 units on a scale
Standard Deviation 0.3

SECONDARY outcome

Timeframe: At Exit (After 30 minutes in each of three interventions)

Slit lamp Biomicroscopy findings were assessed on Efron Grading scales scored to the nearest 0.1 on a scale of 0 - 4 (0=normal, 1=trace, 2=mild, 3=moderate, 4=severe). The assessments were done following the removal of the third intervention. Here the time frame used is "Exit" which refers to those measurements taken post-lens/spectacle wear.

Outcome measures

Outcome measures
Measure
Overall Participants
n=84 Eyes
Total participants who completed the study
Soft Toric Custom Made Contact Lenses
Participants wore a spherical contact lens, a custom-made toric contact lens, and a spectacle correction, each in a random sequence for 30 minutes. Each optical correction was worn in one eye only, with the other eye patched. Participants had either a single eye or both eyes evaluated.
Spectacle Correction
Participants wore a spherical contact lens, a custom-made toric contact lens, and a spectacle correction, each in a random sequence for 30 minutes. Each optical correction was worn in one eye only, with the other eye patched. Participants had either a single eye or both eyes evaluated.
Slit Lamp Biomicroscopy Findings - Limbal Redness
0.9 units on a scale
Standard Deviation 0.3

SECONDARY outcome

Timeframe: Entrance (Prior to wear of study lens)

Slit lamp Biomicroscopy findings were assessed on Efron Grading scales scored to the nearest 0.1 on a scale of 0 - 4 (0=normal, 1=trace, 2=mild, 3=moderate, 4=severe). The assessments done were recorded prior to the first intervention. Here the time frame used is "Entrance" which refers to the time prior to wear of study lens.

Outcome measures

Outcome measures
Measure
Overall Participants
n=84 Eyes
Total participants who completed the study
Soft Toric Custom Made Contact Lenses
Participants wore a spherical contact lens, a custom-made toric contact lens, and a spectacle correction, each in a random sequence for 30 minutes. Each optical correction was worn in one eye only, with the other eye patched. Participants had either a single eye or both eyes evaluated.
Spectacle Correction
Participants wore a spherical contact lens, a custom-made toric contact lens, and a spectacle correction, each in a random sequence for 30 minutes. Each optical correction was worn in one eye only, with the other eye patched. Participants had either a single eye or both eyes evaluated.
Slit Lamp Biomicroscopy Findings - Corneal Staining
0.2 units on a scale
Standard Deviation 0.5

SECONDARY outcome

Timeframe: At Exit (After 30 minutes in each of three interventions)

Slit lamp Biomicroscopy findings were assessed on Efron Grading scales scored to the nearest 0.1 on a scale of 0 - 4 (0=normal, 1=trace, 2=mild, 3=moderate, 4=severe). The assessments were done following the removal of the third intervention. Here the time frame used is "Exit" which refers to those measurements taken post-lens/spectacle wear.

Outcome measures

Outcome measures
Measure
Overall Participants
n=84 Eyes
Total participants who completed the study
Soft Toric Custom Made Contact Lenses
Participants wore a spherical contact lens, a custom-made toric contact lens, and a spectacle correction, each in a random sequence for 30 minutes. Each optical correction was worn in one eye only, with the other eye patched. Participants had either a single eye or both eyes evaluated.
Spectacle Correction
Participants wore a spherical contact lens, a custom-made toric contact lens, and a spectacle correction, each in a random sequence for 30 minutes. Each optical correction was worn in one eye only, with the other eye patched. Participants had either a single eye or both eyes evaluated.
Slit Lamp Biomicroscopy Findings - Corneal Staining
0.3 units on a scale
Standard Deviation 0.5

SECONDARY outcome

Timeframe: Entrance (Prior to wear of study lens)

Slit lamp Biomicroscopy findings were assessed on Efron Grading scales scored to the nearest 0.1 on a scale of 0 - 4 (0=normal, 1=trace, 2=mild, 3=moderate, 4=severe). The assessments done were recorded prior to the first intervention. Here the time frame used is "Entrance" which refers to the time prior to wear of study lens.

Outcome measures

Outcome measures
Measure
Overall Participants
n=84 Eyes
Total participants who completed the study
Soft Toric Custom Made Contact Lenses
Participants wore a spherical contact lens, a custom-made toric contact lens, and a spectacle correction, each in a random sequence for 30 minutes. Each optical correction was worn in one eye only, with the other eye patched. Participants had either a single eye or both eyes evaluated.
Spectacle Correction
Participants wore a spherical contact lens, a custom-made toric contact lens, and a spectacle correction, each in a random sequence for 30 minutes. Each optical correction was worn in one eye only, with the other eye patched. Participants had either a single eye or both eyes evaluated.
Slit Lamp Biomicroscopy Findings - Conjunctival Staining
0.4 units on a scale
Standard Deviation 0.4

SECONDARY outcome

Timeframe: At Exit (After 30 minutes in each of three interventions)

Slit lamp Biomicroscopy findings were assessed on Efron Grading scales scored to the nearest 0.1 on a scale of 0 - 4 (0=normal, 1=trace, 2=mild, 3=moderate, 4=severe). The assessments were done following the removal of the third intervention. Here the time frame used is "Exit" which refers to those measurements taken post-lens/spectacle wear.

Outcome measures

Outcome measures
Measure
Overall Participants
n=84 Eyes
Total participants who completed the study
Soft Toric Custom Made Contact Lenses
Participants wore a spherical contact lens, a custom-made toric contact lens, and a spectacle correction, each in a random sequence for 30 minutes. Each optical correction was worn in one eye only, with the other eye patched. Participants had either a single eye or both eyes evaluated.
Spectacle Correction
Participants wore a spherical contact lens, a custom-made toric contact lens, and a spectacle correction, each in a random sequence for 30 minutes. Each optical correction was worn in one eye only, with the other eye patched. Participants had either a single eye or both eyes evaluated.
Slit Lamp Biomicroscopy Findings - Conjunctival Staining
0.6 units on a scale
Standard Deviation 0.5

SECONDARY outcome

Timeframe: Entrance (Prior to wear of study lens)

Slit lamp Biomicroscopy findings were assessed on Efron Grading scales scored to the nearest 0.1 on a scale of 0 - 4 (0=normal, 1=trace, 2=mild, 3=moderate, 4=severe). The assessments done were recorded prior to the first intervention. Here the time frame used is "Entrance" which refers to the time prior to wear of study lens.

Outcome measures

Outcome measures
Measure
Overall Participants
n=84 Eyes
Total participants who completed the study
Soft Toric Custom Made Contact Lenses
Participants wore a spherical contact lens, a custom-made toric contact lens, and a spectacle correction, each in a random sequence for 30 minutes. Each optical correction was worn in one eye only, with the other eye patched. Participants had either a single eye or both eyes evaluated.
Spectacle Correction
Participants wore a spherical contact lens, a custom-made toric contact lens, and a spectacle correction, each in a random sequence for 30 minutes. Each optical correction was worn in one eye only, with the other eye patched. Participants had either a single eye or both eyes evaluated.
Slit Lamp Biomicroscopy Findings - Papillary Conjunctivitis
1.1 units on a scale
Standard Deviation 0.3

SECONDARY outcome

Timeframe: At Exit (After 30 minutes in each of three interventions)

Slit lamp Biomicroscopy findings were assessed on Efron Grading scales scored to the nearest 0.1 on a scale of 0 - 4 (0=normal, 1=trace, 2=mild, 3=moderate, 4=severe). The assessments were done following the removal of the third intervention. Here the time frame used is "Exit" which refers to those measurements taken post-lens/spectacle wear.

Outcome measures

Outcome measures
Measure
Overall Participants
n=84 Eyes
Total participants who completed the study
Soft Toric Custom Made Contact Lenses
Participants wore a spherical contact lens, a custom-made toric contact lens, and a spectacle correction, each in a random sequence for 30 minutes. Each optical correction was worn in one eye only, with the other eye patched. Participants had either a single eye or both eyes evaluated.
Spectacle Correction
Participants wore a spherical contact lens, a custom-made toric contact lens, and a spectacle correction, each in a random sequence for 30 minutes. Each optical correction was worn in one eye only, with the other eye patched. Participants had either a single eye or both eyes evaluated.
Slit Lamp Biomicroscopy Findings - Papillary Conjunctivitis
1.1 units on a scale
Standard Deviation 0.3

SECONDARY outcome

Timeframe: Entrance (Prior to wear of study lens)

Slit lamp Biomicroscopy findings were assessed on Efron Grading scales scored to the nearest 0.1 on a scale of 0 - 4 (0=normal, 1=trace, 2=mild, 3=moderate, 4=severe). The assessments done were recorded prior to the first intervention. Here the time frame used is "Entrance" which refers to the time prior to wear of study lens.

Outcome measures

Outcome measures
Measure
Overall Participants
n=84 Eyes
Total participants who completed the study
Soft Toric Custom Made Contact Lenses
Participants wore a spherical contact lens, a custom-made toric contact lens, and a spectacle correction, each in a random sequence for 30 minutes. Each optical correction was worn in one eye only, with the other eye patched. Participants had either a single eye or both eyes evaluated.
Spectacle Correction
Participants wore a spherical contact lens, a custom-made toric contact lens, and a spectacle correction, each in a random sequence for 30 minutes. Each optical correction was worn in one eye only, with the other eye patched. Participants had either a single eye or both eyes evaluated.
Slit Lamp Biomicroscopy Findings - Corneal Oedema
0.0 units on a scale
Standard Deviation 0.0

SECONDARY outcome

Timeframe: At Exit (After 30 minutes in each of three interventions)

Slit lamp Biomicroscopy findings were assessed on Efron Grading scales scored to the nearest 0.1 on a scale of 0 - 4 (0=normal, 1=trace, 2=mild, 3=moderate, 4=severe). The assessments were done following the removal of the third intervention. Here the time frame used is "Exit" which refers to those measurements taken post-lens/spectacle wear.

Outcome measures

Outcome measures
Measure
Overall Participants
n=84 Eyes
Total participants who completed the study
Soft Toric Custom Made Contact Lenses
Participants wore a spherical contact lens, a custom-made toric contact lens, and a spectacle correction, each in a random sequence for 30 minutes. Each optical correction was worn in one eye only, with the other eye patched. Participants had either a single eye or both eyes evaluated.
Spectacle Correction
Participants wore a spherical contact lens, a custom-made toric contact lens, and a spectacle correction, each in a random sequence for 30 minutes. Each optical correction was worn in one eye only, with the other eye patched. Participants had either a single eye or both eyes evaluated.
Slit Lamp Biomicroscopy Findings - Corneal Oedema
0.0 units on a scale
Standard Deviation 0.0

Adverse Events

Overall Study

Serious events: 0 serious events
Other events: 4 other events
Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Other adverse events
Measure
Overall Study
n=57 participants at risk
It is not possible to report the adverse Events per intervention as the measurements were taken prior to the first intervention and the following third intervention. Thus, the Adverse Events reporting have been combined. The eye twitch and migraine occurred after wearing all three interventions (Spectacles, Spherical Contact Lens and Toric Contact Lens) and thus these data cannot be subdivided. For the corneal scar and asymptomatic CIE these were observed on study but following wear of their habitual contact lenses and occurred prior to wear of the study interventions and thus these data cannot be further subdivided.
General disorders
Migraine
1.8%
1/57 • The data was collected in the time frame of 90 days
\[Not Specified\]
Eye disorders
Corneal Scar
1.8%
1/57 • The data was collected in the time frame of 90 days
\[Not Specified\]
Eye disorders
asymptomatic corneal infiltrate event
1.8%
1/57 • The data was collected in the time frame of 90 days
\[Not Specified\]
Eye disorders
Twitching in the eye
1.8%
1/57 • The data was collected in the time frame of 90 days
\[Not Specified\]

Additional Information

Jose A. Vega, OD, MSc, FAAO

Coopervision

Phone: 9256213761

Results disclosure agreements

  • Principal investigator is a sponsor employee
  • Publication restrictions are in place