Postoperative Painful Chronicization After Knee Replacement Surgery : Exploratory Study of BDNF's Kinetics
NCT ID: NCT04604847
Last Updated: 2024-06-26
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
200 participants
INTERVENTIONAL
2020-12-04
2024-03-19
Brief Summary
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Chronic postoperative pain (CPOP) is defined by a painful symptomatology in the operated area unrelated to previous pain, present for more than 3 months, and without any link to surgical complication.
The prevalence of chronicization of postoperative pain is 30% after total knee arthroplasty.
Identification of clinical, biological and psychological profiles are crucial to prevent CPOP.
A biologic factor, Brain Derived Neurotrophic Factor (BDNF) produced by a variety of cells is a key regulator of neuroplasticity. BDNF is increasingly studied in the mechanisms of cerebral sensitization and pain chronicization. The role of BDNF in pain of patients remains to be explored in a prospective study. The aim of this observational study is to compare the kinetics of BDNF after total knee arthroplasty in patients with and without CPOP.
Patients will be included in the study at the preanesthetic consultation. Serum BDNF levels will be measured preoperatively, 48h postoperatively, 3 and 6 months after surgery.
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
DIAGNOSTIC
NONE
Study Groups
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Total knee arthroplasty
patient operated for a total knee arthroplasty
blood test
blood test to explore BDNF level
Interventions
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blood test
blood test to explore BDNF level
Eligibility Criteria
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Inclusion Criteria
* Adult patients
* Signed informed consent
* Score ASA (American Society of Anesthesiology) 1-3
* Total knee arthroplasty
Exclusion Criteria
* Pregnant women
* Vulnerable people
* Patients not included in the postoperative rehabilitation program
* Patients unable to complete the pain assessment questionnaires
* Chronic pain patients (other than knee arthrosis)
* Neuropathic pain patients (beforehand)
* Inflammatory diseases, progressive cancer, sepsis, immunosuppression known
18 Years
ALL
No
Sponsors
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Institut National de la Santé Et de la Recherche Médicale, France
OTHER_GOV
University Hospital, Montpellier
OTHER
Responsible Party
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Locations
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Department of Anesthesiology and critical care, Lapeyronie University Hospital
Montpellier, , France
Countries
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Other Identifiers
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RECHMPL19_0192
Identifier Type: -
Identifier Source: org_study_id
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