Secretory Otitis Media in Adenoids Hypertrophy Patients

NCT ID: NCT04584073

Last Updated: 2020-10-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

150 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-10-31

Study Completion Date

2022-12-31

Brief Summary

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This study aims to compare the fate of Secretory Otitis Media in patients with adenoids hypertrophy undergoing Adenoidectomy alone or with Myringotomy or with Myringotomy and Tympanostomy Tube application

Detailed Description

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Otitis media with effusion (OME) is one of the most common diseases during childhood . It is defined as collection of non-purulent effusion (mucoid or serous) in the middle ear space without signs of acute infection. It's synomus are serous otitis media, secretory otitis media or glue ear. Adenoid hypertrophy can cause mechanical obstruction of the Eustachian tube which plays an important role in the pathogenesis of OME.

Management of OME consisted of many varieties; 1- Auto inflation, 2- Medical treatment and 3- Surgical. Surgical treatment indicated in cases where the effusion does not resolve spontaneously or failed medical treatment for 3 months and the main purpose of surgery is to restore middle ear aeration. Treatment options are Adenoidectomy with or without Myringotomy or Myringotomy and Tympanostomy tube application.

The aim of this study is to compare the efficacy of each surgical option in management of otitis media with effusion. This study will be carried out in ENT department of Assiut university hospital on 150 child diagnosed as persistent otitis media with effusion due to adenoid enlargement and they will be categorized randomly into three groups (50 cases per each). Group I will undergo Adenoidectomy alone, group II will undergo Adenoidectomy and Myringotomy and group III will undergo Adenoidectomy and Myringotomy and Tympanostomy tube application. All patients will be subjected to full ENT examination and audiological evaluation. Postoperative evaluation will be done for all patients for 3 months through clinical and audiological evaluation.

Conditions

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Otitis Media With Effusion

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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Adenoidectomy

Adenoidectomy

Group Type ACTIVE_COMPARATOR

Adenoidectomy alone or with Myringotomy or with Myringotomy and Tympanostomy Tube application

Intervention Type PROCEDURE

Adenoidectomy with or without tonsillectomy when indicated will be performed. simple Myringotomy incision will be done in the antero-inferior quadrant of pars tensa of both tympanic membranes. Middle ear fluids will be aspirated. Tympanostomy tube application will be done.

Adenoidectomy and Myringotomy

Adenoidectomy and Myringotomy

Group Type ACTIVE_COMPARATOR

Adenoidectomy alone or with Myringotomy or with Myringotomy and Tympanostomy Tube application

Intervention Type PROCEDURE

Adenoidectomy with or without tonsillectomy when indicated will be performed. simple Myringotomy incision will be done in the antero-inferior quadrant of pars tensa of both tympanic membranes. Middle ear fluids will be aspirated. Tympanostomy tube application will be done.

Adenoidectomy,Myringotomy and Tympanostomy tube application

Adenoidectomy and Myringotomy and Tympanostomy tube application

Group Type ACTIVE_COMPARATOR

Adenoidectomy alone or with Myringotomy or with Myringotomy and Tympanostomy Tube application

Intervention Type PROCEDURE

Adenoidectomy with or without tonsillectomy when indicated will be performed. simple Myringotomy incision will be done in the antero-inferior quadrant of pars tensa of both tympanic membranes. Middle ear fluids will be aspirated. Tympanostomy tube application will be done.

Interventions

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Adenoidectomy alone or with Myringotomy or with Myringotomy and Tympanostomy Tube application

Adenoidectomy with or without tonsillectomy when indicated will be performed. simple Myringotomy incision will be done in the antero-inferior quadrant of pars tensa of both tympanic membranes. Middle ear fluids will be aspirated. Tympanostomy tube application will be done.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Any case presented with Secretory Otitis Media with adenoids hypertrophy with the following criteria
* Age is between 3 to 17 years old
* With or without chronic tonsillitis
* conductive hearing loss
* Recurrent upper respiratory tract infection
* Dull tympanic membrane on otoscopy (absent cone of light), decreased mobility of tympanic membrane
* Type B tympanogram on tympanometry
* OME not responding to medical treatment for three months

Exclusion Criteria

* Patients with the following criteria will be excluded from the study
* Previous Myringotomy with or without Tympanostomy Tube application
* Previous adenoidectomy or tonsillectomy
* Previous ear surgery, cleft palate, Down's syndrome, congenital malformation of the ear and cholesteatoma.
Minimum Eligible Age

3 Years

Maximum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Assiut University

OTHER

Sponsor Role lead

Responsible Party

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Ahmed Ayman Ahmed Mostafa Abokrisha

Resident

Responsibility Role PRINCIPAL_INVESTIGATOR

Central Contacts

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Ahmed Ayman Ahmed, Resident

Role: CONTACT

+201060451679

Ahmed Abd El-Hay El-Hussiney, professor

Role: CONTACT

01220701447

References

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Popova D, Varbanova S, Popov TM. Comparison between myringotomy and tympanostomy tubes in combination with adenoidectomy in 3-7-year-old children with otitis media with effusion. Int J Pediatr Otorhinolaryngol. 2010 Jul;74(7):777-80. doi: 10.1016/j.ijporl.2010.03.054.

Reference Type RESULT
PMID: 20399511 (View on PubMed)

Xu WM, Ye YH. [Effect of tympanostomy tube insertion with adenoidectomy for children with recurrent otitis media with effusion]. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Dec;30(23):1873-1875. doi: 10.13201/j.issn.1001-1781.2016.23.009. Chinese.

Reference Type RESULT
PMID: 29798016 (View on PubMed)

Tian X, Liu Y, Wang M, Liu H. [A systematic review of adenoidectomy in the treatment of otitis media with effusion in children]. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2014 Apr;29(8):723-5. Chinese.

Reference Type RESULT
PMID: 26248446 (View on PubMed)

Hao J, Chen M, Liu B, Yang Y, Liu W, Ma N, Han Y, Liu Q, Ni X, Zhang J. Compare two surgical interventions for otitis media with effusion in young children. Eur Arch Otorhinolaryngol. 2019 Aug;276(8):2125-2131. doi: 10.1007/s00405-019-05421-9. Epub 2019 May 24.

Reference Type RESULT
PMID: 31127413 (View on PubMed)

Other Identifiers

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OME in adenoids hypertrophy

Identifier Type: -

Identifier Source: org_study_id

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