Adjuvant Adenoidectomy for the Treatment of Chronic OME in Children

NCT ID: NCT05545345

Last Updated: 2022-09-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

380 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-09-30

Study Completion Date

2025-09-30

Brief Summary

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This study aims to verify the efficacy of adjuvant adenoidectomy for children with chronic OME who become candidates for tympanostomy tube placement, and explore potential factors associated with the efficacy of adjuvant adenoidectomy.

Detailed Description

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Otitis media with effusion is a common condition in children, and tympanostomy tube placement is the first-line treatment for those who requires surgical interventions. Adenoidectomy proves to be helpful to children over 4 years old, but the risks of adjuvant surgery is believed to somehow offset its benefits. This study is meant to verify if concurrent adenoidectomy provides extra benefits in resolving MEE, reducing AOM, and improving hearing and patients' quality of life to children who become candidates for TT.

Conditions

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Otitis Media With Effusion in Children

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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TT

Participants only receive tympanostomy tube placement.

Group Type ACTIVE_COMPARATOR

tympanostomy tube placement

Intervention Type PROCEDURE

An incision will be made in the the tympanic membrane, through which a ventilation tube will be inserted.

Ad+TT

Participants will receive tympanostomy tube placement and concurrent adenoidectomy.

Group Type EXPERIMENTAL

tympanostomy tube placement

Intervention Type PROCEDURE

An incision will be made in the the tympanic membrane, through which a ventilation tube will be inserted.

adenoidectomy

Intervention Type PROCEDURE

The adenoid is resected transorally under a 70° endoscope with microdebrider or coblator until torus tubarius and choanae are completely revealed.

Interventions

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tympanostomy tube placement

An incision will be made in the the tympanic membrane, through which a ventilation tube will be inserted.

Intervention Type PROCEDURE

adenoidectomy

The adenoid is resected transorally under a 70° endoscope with microdebrider or coblator until torus tubarius and choanae are completely revealed.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* 1\. Children 4-12 years of age.
* 2\. Diagnosed with chronic OME. Diagnostic criteria: I. Middle ear effusion detected by otoscopy; II. Type B or C tympanograms; III. Symptoms/signs of OME persisted for \>3 months;
* 3\. Documented hearing loss ≥20dB (average threshold of 500Hz, 1000Hz and 2kHz in pure tone audiometry).
* 4\. Adenoid hypertrophy (A/N ratio\> 0.5 in lateral radiography of the nasopharynx).
* 5\. Informed consent given by the patients and their guardians.

Exclusion Criteria

1. Cleft palate or other systemic disorders.
2. Patients are diagnosed with other nose, sinuses or ear diseases that are eligible for surgical treatment.
3. Patients are diagnosed with OSAHS, tonsil hypertrophy ≥II° or scheduled for tonsillectomy.
4. History of tympanostomy tube placement.
5. Infection of the upper respiratory tract or acute rhinosinusitis over the past 7 days.
6. Sensorineural hearing loss.
7. Other situations that the investigators find unsuitable for the trial.
Minimum Eligible Age

4 Years

Maximum Eligible Age

12 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Xinhua Hospital, Shanghai Jiao Tong University School of Medicine

OTHER

Sponsor Role collaborator

Children's Hospital of Fudan University

OTHER

Sponsor Role collaborator

Eye & ENT Hospital of Fudan University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Central Contacts

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Huiqian Yu, PhD

Role: CONTACT

86-13636423139

Fangzhou Yu, MD

Role: CONTACT

86-18321719732

Other Identifiers

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2022-AdOME

Identifier Type: -

Identifier Source: org_study_id

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