The Effect of Desflurane on Postopertative Cognitive Dysfunction
NCT ID: NCT04541823
Last Updated: 2021-08-19
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
PHASE4
100 participants
INTERVENTIONAL
2021-05-01
2023-03-31
Brief Summary
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Detailed Description
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Desflurane is a widely used volatile anesthetic, associated with shorter emergence times than other volatile anesthetics. This study aims to access the effect of desflurane in preventing postoperative cognitive dysfunction.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
DOUBLE
Study Groups
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Desflurane
Patients allocated to this arm will receive desflurane during the maintenance of anesthesia.
Desflurane
Investigators administrated desflurane with target of BIS 40-60 during the maintenance of anesthesia
Propofol
Patients allocated to this arm will receive propofol during the maintenance of anesthesia
Propofol
Investigators administrated propofol with target of BIS 40-60 during the maintenance of anesthesia
Interventions
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Desflurane
Investigators administrated desflurane with target of BIS 40-60 during the maintenance of anesthesia
Propofol
Investigators administrated propofol with target of BIS 40-60 during the maintenance of anesthesia
Eligibility Criteria
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Inclusion Criteria
* 2\. Scheduled to undergo elective non-cardiac surgeries under general anesthesia
* 3\. ASA Physical Score I-III
Exclusion Criteria
* 2\. Patients with a history of psychiatric disease
* 3\. Patients with a medication history of antipsychotic drugs.
* 4\. Unable to complete neuropsychological testing including patients with severe visual or hearing impairment.
* 5\. Patients with preoperative delirium.
* 6\. Patients who have severe adverse events, such as cardiac arrest.
* 7\. Patients who preoperative MMSE score are below 20;
* 8\. Patients who undergo second operation in a short period.
65 Years
ALL
No
Sponsors
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Beijing Chao Yang Hospital
OTHER
Responsible Party
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Anshi Wu
Head of Anesthesiology
Locations
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Beijing Chaoyang Hospital, Capital Medical University
Beijing, Beijing Municipality, China
Countries
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Facility Contacts
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Other Identifiers
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00375928
Identifier Type: -
Identifier Source: org_study_id
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