Different Anesthetic Strategies on Postoperative Cognitive Function and Delirium in Patients Undergoing Cardiac Surgery
NCT ID: NCT04505059
Last Updated: 2022-03-15
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
502 participants
INTERVENTIONAL
2020-09-11
2023-01-18
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
QUADRUPLE
Study Groups
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Precision cardiac anesthesia
Remifentanil (TCI) for intra-operative analgesia Propofol (TCI) for intra-operative sedation
Precision cardiac anesthesia
Aperi-operative anesthetic management through target-controlled infusion to accurately control the patient blood concentration, with combination of bispectral index and neuromuscular monitoring to adjust the dosage of general anesthetics.
Conventional cardiac anesthesia
Institutional standard of care.
Conventional cardiac anesthesia
The anesthesia strategy is mainly depending on the anesthesiologist's clinical experience
Interventions
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Precision cardiac anesthesia
Aperi-operative anesthetic management through target-controlled infusion to accurately control the patient blood concentration, with combination of bispectral index and neuromuscular monitoring to adjust the dosage of general anesthetics.
Conventional cardiac anesthesia
The anesthesia strategy is mainly depending on the anesthesiologist's clinical experience
Eligibility Criteria
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Inclusion Criteria
2. ASA:I to III;
3. Hemodynamic stability, LVEF≥40%;
4. Cardiac surgery including CABG, valve surgery, CABG combined with valve surgery, surgical repair of ASD,VSD and atrial myxoma, and other types.
Exclusion Criteria
2. Emergency cases, heart transplantation;
3. Severe hepatic insufficiency (Child-Pugh grades C),Severe renal insufficiency (requirement of renal replacement therapy);
4. Previous history of drug and alcohol abuse,allergy to general anesthetics;
5. Preoperative severe dementia, language barrier and mental illness
6. Preoperative schizophrenia, epilepsy, stroke and Parkinson's disease
7. Previous history of craniocerebral injury or neurosurgery;
8. Any other conditions that are considered unsuitable for study participation.
18 Years
ALL
No
Sponsors
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Tianjin Chest Hospital
OTHER
The Second Hospital of Hebei Medical University
OTHER
China National Center for Cardiovascular Diseases
OTHER_GOV
Responsible Party
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Yuefu Wang
Professor
Principal Investigators
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Yuefu Wang, MD
Role: STUDY_DIRECTOR
Fuwai Hospital, China National Center for Cardiovascular Diseases, CAMS&PUMC
Jiange Han, MD
Role: PRINCIPAL_INVESTIGATOR
Tianjin Chest Hospital
Haitao Liu, MD
Role: PRINCIPAL_INVESTIGATOR
The Second Hospital of Hebei Medical University
Locations
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The Second Hospital of HeBei Medical University
Shijiazhuang, Hebei, China
Fuwai Hospital, China National Center for Cardiovascular Diseases, CAMS&PUMC
Beijing, , China
Tianjin Chest Hospital
Tianjin, , China
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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Precision-Delirium-Cognitive
Identifier Type: -
Identifier Source: org_study_id
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