Association of Oral Lichen Planus and Thyroid Disease

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-01-01

Study Completion Date

2020-04-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Thyroid disease is a common endocrine disorder. Oral lichen planus (OLP) is a chronic autoimmune disease that occurs on the oral mucosa in 1-2% of the general population.The purpose of this study was to determine whether there is an association between thyroid disease and oral planus lichen in the population of our patients. In the last few years, a couple of studies have been published in the world literature that have studied the possible association of these diagnoses in different populations. Most of the results showed a higher prevalence of thyroid disease in the population of lichen patients, compared with patients without lichen, although some results are contradictory. Some authors believe that the onset of OLP precedes thyroid dysfunction. In the population of Croatian patients with lichen, no research has been done to study the possible connection between these two diseases. The obtained results could help clarify whether there is a connection between these two diagnoses in the population of our lichen patients and enable earlier detection of patients with thyroid hypofunction.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Relationship Between Oral Lichen Planus and Autoimmune Thyroid Diseases

NCT05403216

Oral Lichen Planus

COMPLETED

Serum Cortisol Levels in Patients With Anxiety and Depression With Symptomatic Oral Lichen Planus

NCT03011658

Oral Lichen Planus Related Stress

COMPLETED NA

HLA-DRB1 and HLA-DQB1 Genotyping for Autoantibody-positive and -Negative Patients With Atrophic Glossitis or Burning Mouth Syndrome

NCT01931293

Atrophic Glossitis, Burning Mouth Syndrome

UNKNOWN NA

Salivary and Serum Leptin Levels in Oral Lichen Planus Patients: A Case-control Study.

NCT06078579

Oral Lichen Planus Leptin Levels

COMPLETED

Based on Metabonomics Dryness Pathogen Type of OLP: a Dynamic Study

NCT02332486

Oral Lichen Planus

UNKNOWN NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Oral Lichen Planus Thyroid Diseases

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Oral lichen planus

Female patients of the Department of Oral Medicine with oral lichen planus

determination of thyroid hormones and antibodies

Intervention Type DIAGNOSTIC_TEST

TSH, fT3, fT4, anti-TPO and anti-Tg were determined from blood sample

Control

Female patients of the Department of Oral Medicine without oral lichen planus or other immune disorders

determination of thyroid hormones and antibodies

Intervention Type DIAGNOSTIC_TEST

TSH, fT3, fT4, anti-TPO and anti-Tg were determined from blood sample

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

determination of thyroid hormones and antibodies

TSH, fT3, fT4, anti-TPO and anti-Tg were determined from blood sample

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* for test group: female patients of the Department of Oral Medicine School of Dental Medicine University of Zagreb with clinically and histopathologically confirmed oral lichen planus
* for control group: female patients of the Department of Oral Medicine School of Dental Medicine University of Zagreb, without oral lichen planus or other immune disorders; age matched to test group