Effects of Denture-Related Stomatitis on Blood Pressure in Denture Wearers

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

80 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-10-31

Brief Summary

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The aim of this study is to evaluate the influence of presence of oral fungal infection, which leads to denture-related stomatitis, on blood pressure, endothelial function and immune cell phenotype in patients wearing dentures.

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Detailed Description

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Conditions

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Denture Stomatitis

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Control group

Denture wearers without clinical signs of denture-related stomatitis confirmed with negative Candida swabs.

No interventions assigned to this group

Denture-related stomatitis group

Denture wearers with clinical signs of denture-related stomatitis, confirmed with positive Candida swabs.

Treated for fungal infection, with nystatin \[100 000 IU every 6 h for 3 weeks, applied on the infected area of the mucous membrane of the palate and cheeks\].

Nystatin

Intervention Type DRUG

100 000 IU every 6 h as a suspension

Interventions

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Nystatin

100 000 IU every 6 h as a suspension

Intervention Type DRUG

Other Intervention Names

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Mycostatin Stamicin Stamycin Fungicidin Nilstat

Eligibility Criteria

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Inclusion Criteria

* Patients with dental prostheses used for at least 6 months,
* Substantial portion of the oral mucosa covered by dental prosthesis.

Exclusion Criteria

* acute inflammatory disorders other than denture-related stomatitis, neoplastic disease relapses or chemotherapy courses less than 5 years before the enrolment,
* antibiotics in less than 4 weeks before the enrolment,
* anti-inflammatory drugs (steroids and non-steroidal, excluding aspirin in doses less than 80 mg) in less than 2 months before the enrolment,
* history of myocardial infarction, acute coronary incident or vascular inflammation in 5 weeks or less before the enrolment,
* chronic haematological disorders and immunodeficiencies less than 5 weeks before the enrolment,
* major medication changes less than 5 weeks before the enrolment or during study.

Eligible Sex

ALL

Accepts Healthy Volunteers

No