Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
2000 participants
OBSERVATIONAL
2015-04-30
2015-12-31
Brief Summary
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Detailed Description
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ICU patients are at increased risk for oropharyngeal dysphagia following endotracheal intubation. However, the incidence, respective underlying causes and clinical consequences of dysphagia in ICU patients are currently understudied. The impact on clinical outcomes of respective ICU patients thus remains currently unclear. A systematic review \[1\] reported highly variable dysphagia frequency rates depending on the time of mechanical ventilation/ intubation.
However, previous clinical trials were heterogeneous in design, methods of screening, and study outcome. The overall quality of evidence is considered low. The systematic review highlights the limited available evidence for dysphagia following intubation and hence the need for high-quality prospective trials. A recent retrospective single-centre trial \[2\] in a tertiary care ICU demonstrated a high presence of dysphagia in mechanical ventilated (MV) patients following extubation. Screening was performed using bedside swallowing evaluation (BSE).
In a prospective observational analysis, we aim to further elucidate the impact of dysphagia on respective clinical outcomes in ICU patients after mechanical ventilation.
Conditions
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Study Design
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PROSPECTIVE
Eligibility Criteria
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Exclusion Criteria
* patients post oesophageal resection / with oesophageal rupture
18 Years
ALL
No
Sponsors
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Nestec S.A., Switzerland (Funding)
UNKNOWN
Insel Gruppe AG, University Hospital Bern
OTHER
Responsible Party
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Jörg Schefold
Principal Investigator/ Coordinating Investigator
Principal Investigators
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Jukka Takala, Prof Dr.
Role: STUDY_CHAIR
University of Bern, Inselspital
Stephan Jakob, Prof. Dr.
Role: STUDY_CHAIR
University of Bern, Inselspital
Joerg C Schefold, MD
Role: PRINCIPAL_INVESTIGATOR
University of Bern, Inselspital
Locations
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Dept. of Intensive Care Medicine, University of Bern,
Bern, , Switzerland
Countries
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References
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Skoretz SA, Flowers HL, Martino R. The incidence of dysphagia following endotracheal intubation: a systematic review. Chest. 2010 Mar;137(3):665-73. doi: 10.1378/chest.09-1823.
Macht M, King CJ, Wimbish T, Clark BJ, Benson AB, Burnham EL, Williams A, Moss M. Post-extubation dysphagia is associated with longer hospitalization in survivors of critical illness with neurologic impairment. Crit Care. 2013 Jun 20;17(3):R119. doi: 10.1186/cc12791.
Zuercher P, Schenk NV, Moret C, Berger D, Abegglen R, Schefold JC. Risk Factors for Dysphagia in ICU Patients After Invasive Mechanical Ventilation. Chest. 2020 Nov;158(5):1983-1991. doi: 10.1016/j.chest.2020.05.576. Epub 2020 Jun 7.
Other Identifiers
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Dynamics
Identifier Type: -
Identifier Source: org_study_id
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