Autologous Oral Mucosa Transplantation for Limbal Stem Cell Deficiency
NCT ID: NCT03226015
Last Updated: 2017-07-21
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
27 participants
OBSERVATIONAL
2015-07-31
2017-05-31
Brief Summary
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DESIGN: Prospective observational study.
METHODS: 32 eyes of 27 patients with limbal stem cell deficiency underwent direct oral mucosa graft transplantation with amniotic membrane transplantation with a mean follow-up of 19 months. Clinical course of the disease including emergency surgeries, planned curative procedures, conjunctival inflammation, acute inpatient treatment and best corrected visual acuity were assessed at 3 months postoperatively and at last follow up visit. The unneeded parts of oral mucosa graft were analyzed immunohistochemically with staining for mesenchymal stem cell markers and pericytes (CD 90, CD 146, CD 166, CD 31, CD 68, protein gene product).
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Detailed Description
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Conditions
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Study Design
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CASE_ONLY
PROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
* undergoing oral mucosa with amniotic membrane transplantation
* obtained written informed consent
Exclusion Criteria
18 Years
ALL
No
Sponsors
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Institute of Anatomy TU Dresden
UNKNOWN
Klinikum Chemnitz gGmbH
OTHER
Responsible Party
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Katrin Engelmann
Head of Ophthalmology
Principal Investigators
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Katrin Engelmann, PhD
Role: PRINCIPAL_INVESTIGATOR
Klinikum Chemnitz
Other Identifiers
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EK-BR-64/15-1
Identifier Type: -
Identifier Source: org_study_id
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