Circulating Tumor Cells (CTC) in Cancer

NCT ID: NCT04520672

Last Updated: 2025-03-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

3000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-10-01

Study Completion Date

2030-08-31

Brief Summary

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This observational study with circulating tumor cells (CTC) count, isolation and analysis at several time points during disease progression is to investigate the role and biology of CTCs and clusters of CTCs in different cancer types. It also evaluates the role of CTCs as biomarkers, and aims at the identification of key signaling networks that are active in CTCs.

Detailed Description

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Conditions

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Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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Blood samples

Blood samples (3 ethylenediaminetetraacetic acid (EDTA) tubes with a volume of 7.5 ml blood each) will be processed for CTC isolation and characterization, ranging from molecular analysis to culture and drug screen.

Intervention Type OTHER

Samples from tumor draining vessels

In case of tumor resection, 3 EDTA tubes (5 ml) will be withdrawn from the tumor draining vessels for CTC isolation and characterization, ranging from molecular analysis to culture and drug screen.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Adult cancer patients
* All patients with histology-based proved diagnosis of cancer, all stages and subtypes can be included. Precancerous lesions cannot be included.
* All patients with the diagnosis of a solid tumor including adenocarcinoma, squamous cell carcinoma, neuroendocrine carcinoma, sarcoma
* Written pathology report must be available.
* Written informed consent.

Exclusion Criteria

* No written informed consent.
* No proved diagnosis of malignancy by pathology report.
* Patients with the diagnosis of blood cancer
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Basel, Switzerland

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Marcus Vetter, PD Dr. med.

Role: PRINCIPAL_INVESTIGATOR

Kantonsspital Baselland, Liestal

Locations

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University Hospital Basel

Basel, , Switzerland

Site Status RECRUITING

Department Oncology, Haematology & Immuntherapy, Kantonsspital Baselland

Liestal, , Switzerland

Site Status RECRUITING

Countries

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Switzerland

Central Contacts

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Marcus Vetter, PD Dr. med.

Role: CONTACT

+41 61 925 27 15

Nicola Aceto, Prof. Dr. med.

Role: CONTACT

+41 44 633 40 23

Facility Contacts

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Christian Kurzeder, PD Dr. med.

Role: primary

+41 61 265 2525

Marcus Vetter, PD Dr. med.

Role: primary

+41 61 925 27 15

Other Identifiers

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2020-00014; me19Vetter

Identifier Type: -

Identifier Source: org_study_id

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