Perioperative Lactate Kinetics in Patient Undergoing Major Liver Surgery

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

55 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-01-01

Study Completion Date

2019-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Major liver surgery is associated with increased incidence of perioperative complications and increased mortality if these are not addressed quickly in a high dependency intensive care unit. Of these, posthepatectomy liver failure (PHLF) represents one of the most important cause of postoperative unfavourable outcome. The present study investigates the correlation between lactate levels and PHLF. Lactate levels were collected at six specific timepoints: preoperative, pre-dissection phase, post-dissection phase, end of surgery and 24-hours and 48-hours in the postoperative period.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Implication of Fluid Strategies Upon Hepatic Outcome in Hepatobiliary Surgery

NCT03923816

Hepatic Complication

UNKNOWN PHASE1/PHASE2

Predictor of Postoperative Complications After Lengthy Noncardiac Surgery

NCT04680663

Peripheral Perfusion Index

COMPLETED

"Duration of Preoperative Clear Fluids Fasting in Patients Undergoing Liver Transplant"

NCT07288281

Preoperative Clear Fluid Fasting Liver Transplant Recipient

RECRUITING

Phlebotomy to Prevent Blood Loss in Major Hepatic Resections

NCT02548910

Liver Neoplasms Hepatectomy

COMPLETED NA

The Effect of Remote Ischemic Preconditioning in Patients Undergoing Major Liver Surgery

NCT00796588

Ischemia Reperfusion Injury

UNKNOWN NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Liver Failure, Acute

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

major liver surgery

Patients undergoing major liver surgery

serum lactate

Intervention Type DIAGNOSTIC_TEST

perioperative measurement of lactate levels

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

serum lactate

perioperative measurement of lactate levels

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* patients undergoing major liver surgery for primary or secondary tumours

Exclusion Criteria

* unsigned patient consent
* death within 24 hours
* need for perioperative renal replacement therapy
* underlying liver disease (e.g. liver cirrhosis)
* other causes of raised lactate levels (e.g. shock)

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No