Lung Function After Abdominal Surgery

NCT ID: NCT04502420

Last Updated: 2023-01-25

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 59 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2020-08-17
• Study Completion Date: 2021-10-17

Brief Summary

The study aims to investigate changes in lung function and diffusion capacity for carbon monoxide after open and minimally invasive abdominal surgery and whether such changes can explain hypoxia after surgery.

Inclusion: Patients undergoing surgery for abdominal surgery

Exclusion: Dementia or cognitive impairment that makes it impossible to participate in studies.

Investigation: The day before surgery and the day after surgery

Primary outcome measures:

• Pulmonary function test with dynamic spirometry (Vital capacity, FEV1) and diffusion capacity for carbon monoxide.
• PaO2, PaCO2 and oxygen saturation (blood gas)

Detailed Description

Postoperative hypoxia complicates 30% - 50% of abdominal surgeries. People at particular risk for postoperative pulmonary complications including severe hypoxia are those who undergo abdominal surgery, emergency surgery or have a respiratory failure due to chronic lung disease including obstructive sleep apnea. The cause of postoperative restrictive lung function and hypoxia is unknown. Previous studies report that PaO2 decreases by an average of 2 kPa after abdominal surgery, while PaCO2 is unchanged and vital capacity decreases by 35%.

The study aims to investigate changes in lung function and diffusion capacity for carbon monoxide after open and minimally invasive abdominal surgery and whether such changes can explain hypoxia after surgery.

Design: Prospective cohort study

Inclusion: Patients undergoing surgery for abdominal surgery

Exclusion: Dementia or cognitive impairment that makes it impossible to participate in studies.

Method: The day before surgery and the day after surgery: Lung function (Vital capacity and FEV1) using box and diffusion capacity measurements and blood gas measurement

Primary outcome measures:

• Pulmonary function test with dynamic spirometry (Vital capacity, FEV1) and diffusion capacity for carbon monoxide.
• PaO2, PaCO2 and oxygen saturation (blood gas) Other variables examined: age, sex, height, weight, type of surgery, type of anesthesia, smoking status, length of surgery, previously known lung disease.

Conditions

Lung Function; Postoperative Complications; Abdominal Surgery

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Abdominal surgery

People who to be operated in the abdomen are investigated before and after surgery.

Lung function before and after surgery

Intervention Type: DIAGNOSTIC_TEST

A diagnostic test

Interventions

Lung function before and after surgery

A diagnostic test

Intervention Type: DIAGNOSTIC_TEST

Other Intervention Names

Diffusion capacity and arterial blood gas before and after surgery.

Eligibility Criteria

Inclusion Criteria

• Adult patients (18 years old and older) scheduled for surgery in the abdomen at department of Surgery, Urology and Gynecologi, Umeå University hospital.
• Must be able to perform a lung function test

Exclusion Criteria

• Dementia or severe cognitive impairment

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Karolinska Institutet

OTHER

Sponsor Role: collaborator

Umeå University

OTHER

Sponsor Role: lead

Responsible Party

Karl A Franklin

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Karl A Franklin, Prof

Role: PRINCIPAL_INVESTIGATOR

Inst Surgical and periopertive sciences, Umeå university, Sweden

Locations

Dept surgery,

Umeå, , Sweden

Countries

Sweden

Other Identifiers

2018-223-31M

Identifier Type: -

Identifier Source: org_study_id