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THE EFFECT OF ALVEOLAR RECRUITMENT MANOEUVRE ON INTRAOPERATIVE HAEMODYNAMICS

NCT ID: NCT07299396

Last Updated: 2025-12-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

70 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-01-09

Study Completion Date

2023-08-15

Brief Summary

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Alveolar recruitment manoeuvre plays a key role in the prevention of atelectasis. In addition, it affects haemodynamic parameters. This study aims to investigate the effects of RM on haemodynamic parameters using minimally invasive monitoring techniques.

Detailed Description

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During laparoscopic hysterectomy, pneumoperitoneum is created with carbon dioxide (CO₂) to provide surgical field of view and the patient is placed in Trendelenburg position. This increases intrathoracic pressure, decreases lung compliance and increases the risk of atelectasis. Therefore, lung protective ventilation strategies such as alveolar recruitment manoeuvre (RM), individualised PEEP application and low tidal volume are recommended. RM aims to increase lung compliance and prevent atelectasis by reopening collapsed alveoli. However, changes in haemodynamic parameters, especially mean arterial pressure and cardiac output, may occur during RM. In addition to standard monitoring for the management of these changes, haemodynamic evaluation can be performed with minimally invasive methods such as arterial waveform analysis. In this study, we aimed to evaluate the effects of RM applied during laparoscopic hysterectomy on intraoperative haemodynamic parameters using arterial waveform analysis.

Conditions

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ASA Class I/II Patients Scheduled for Surgery Under General Anesthesia Laparoscopic Hysterectomy

Keywords

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lung protective ventilation recruitment manoeuvre laparoscopic surgery haemodynamic changes

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Alveolar Recruitment Maneuver Applied

No interventions assigned to this group

Alveolar Recruitment Maneuver Not Applied

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* ASA Class 1-2 patients 18-70 years old

Exclusion Criteria

* \<18 y, BMI\>40
* Patients receiving invasive mechanical ventilator support in the last 1 month
* Patients who have received chemotherapy or radiotherapy in the last 2 months
* Those with severe lung disease (COPD, asthma, pulmonary infection, bronchiectasis, previous need for non-invasive mechanical ventilation, oxygen therapy or steroid therapy for acute attack)
* Known severe pulmonary hypertension
* Patient refusal to participate in the study
* Intracranial tumour
* Haemodynamic instability
* Shock
* Neuromuscular disease
* Pathologies causing increased intracranial and intraocular pressure
* Atrial fibrillation
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Balikesir University

OTHER

Sponsor Role lead

Responsible Party

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Ozlem Sagir, MD

Professor, MD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Ahmet Koroglu, Professor, medical doctor

Role: STUDY_CHAIR

Balikesir University

Locations

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Balikesir University

Balıkesir, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

Other Identifiers

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BalikesirU OSagır 001

Identifier Type: -

Identifier Source: org_study_id