Effects of Anesthesia on Atelectasis

NCT ID: NCT06790901

Last Updated: 2025-01-24

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 90 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2023-09-15
• Study Completion Date: 2025-01-12

Brief Summary

We know that respiratory functions of patients are affected under general anaesthesia. Although there are many underlying causes of ventilation-perfusion mismatch in the airways, the main cause is atelectasis during general anaesthesia.

Atelectasis occurs in almost all patients receiving general anaesthesia. The main cause of atelectasis is the loss of muscle tone during general anaesthesia. Postoperative atelectasis was described in the last century. It is defined as the closure of the alveoli due to a decrease in inspiratory force and collapse of the lung and the resulting loss of aeration.

Inhalation anaesthetics have been shown to cause hypoxic pulmonary vasoconstriction in studies. However, not all inhalation anaesthetics affect the airways in the same way.

In patients who will undergo surgical procedures under different general anaesthesia maintenance methods, conditions that disrupt the ventilation-perfusion balance in the lung peroperatively can be diagnosed and monitored early, easily and inexpensively by lung ultrasonography.

Lung ultrasound is a noninvasive, reliable, reliable, radiation-free imaging method that provides instantaneous imaging at the bedside. Lung ultrasound score is a scoring system that provides scoring of the loss of ventilation in the lung. For this purpose, it was aimed to divide both lung tissues into 12 areas and to give a score between 0 and 3 points and to show the severity of the loss of aeration according to the resulting total score.

Conditions

Atelectasis; General Aneshesia

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Group Total IV anesthesia

LUNG ULTRASOUND

Intervention Type: PROCEDURE

Determination of atelectsis By Lung Ultrasound Score

Group Sevoflurane

LUNG ULTRASOUND

Intervention Type: PROCEDURE

Determination of atelectsis By Lung Ultrasound Score

Group Desflurane

LUNG ULTRASOUND

Intervention Type: PROCEDURE

Determination of atelectsis By Lung Ultrasound Score

Interventions

LUNG ULTRASOUND

Determination of atelectsis By Lung Ultrasound Score

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

• 18-65 years old ASA I-II Surgical procedure time between 2 hours and 5 hours in supine position Patients who will undergo rhinoplasty, septorhinoplasty operation Patients whose consent was obtained with an informed consent form

Exclusion Criteria

• Those with a history of malignant hyperthermia,
• People with alcohol or drug addiction,
• Presence of dementia or confusion,
• Uncooperative patients,
• Those with respiratory disease,
• Those with coronary artery disease, congestive heart failure,
• Patients with unstable blood pressure,
• Significant anaemia, liver or kidney disease,
• Women during pregnancy or lactation,
• Allergy to anaesthetic agents,
• Body mass index (BMI) >30 kg/m2,
• Those with sepsis or bacterial infection, Body temperature below 35°C and above 38°C at control value

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Zonguldak Bulent Ecevit University

OTHER

Sponsor Role: lead

Responsible Party

Oguzhan Karayaka

MD

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Zonguladk Bulent ecevit University

Zonguldak, Kozlu, Turkey (Türkiye)

Countries

Turkey (Türkiye)

Other Identifiers

2023/16-6

Identifier Type: -

Identifier Source: org_study_id