High-flow Nasal Cannula Oxygenation Decrease Hypoxia in Sedated Gastrointestinal Endoscopes in Obesity
NCT ID: NCT04500392
Last Updated: 2024-01-11
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
1000 participants
INTERVENTIONAL
2021-05-06
2024-01-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
SINGLE
Study Groups
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Control group
Oxygen(up to 6L/min) supplied with a regular nasal catheter
Regular nasal cannula
Oxygen is supplied with a regular nasal cannula #the flow is up to 6L/min
High-flow nasal cannula group
Oxygen(up to 60L/min) supplied with high-flow nasal cannula
High-flow nasal cannula oxygenation
Oxygen is supplied with a high-flow nasal cannula oxygenation device#the flow is up to 60L/min
Interventions
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High-flow nasal cannula oxygenation
Oxygen is supplied with a high-flow nasal cannula oxygenation device#the flow is up to 60L/min
Regular nasal cannula
Oxygen is supplied with a regular nasal cannula #the flow is up to 6L/min
Eligibility Criteria
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Inclusion Criteria
* age≥18 years old and ≤70 years old
* patients or family members signed informed consent form
* ASA classification I-II
* BMI≥ 28kg/m²
Exclusion Criteria
* An episode/exacerbation of congestive heart failure (CHF) that requires a change in medication, diet or hospitalization from any cause in the last 6 months;
* Severe aortic stenosis or mitral stenosis;
* Cardiac surgery involving thoracotomy (e.g., coronary artery bypass graft (CABG), valve replacement surgery) in the last 6 months;
* Acute myocardial infarction in the last 6 months;
* Acute arrhythmia (including any tachycardia - or bradycardia) with the fluid of hemodynamics instability;
* Diagnosed chronic obstructive pulmonary disease or current other acute or chronic lung disease requiring supplemental chronic or intermittent oxygen therapy);
* Increased intracranial pressure;
* ASA classification Ⅲ-Ⅳ ;
* Mouth, nose, or throat infection;
* Liver and kidney disease
* Fever, defined as core body temperature \> 37.5℃;
* Pregnancy, breastfeeding or positive pregnancy test;
* Emergency procedure;
* Patients or family members refused to participate
* Mental disorders and people without civil capacity
18 Years
70 Years
ALL
No
Sponsors
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Shanghai Tongji Hospital, Tongji University School of Medicine
OTHER
Shanghai Oriental Hospital, Tongji University School of Medicine
UNKNOWN
RenJi Hospital
OTHER
Responsible Party
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diansan su
Vice Chair of the Department of Anesthesiology
Principal Investigators
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Diansan Su, Dr.
Role: PRINCIPAL_INVESTIGATOR
Renji Hospital, Shanghai Jiaotong University, Shanghai, China
Locations
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Shanghai Tongji Hospital
Shanghai, Shanghai, China, China
Shanghai Oriental Hospital
Shanghai, Shanghai, China, China
Renji hospital, School of Medicine, Shanghai Jiaotong University
Shanghai, Shanghai, China, China
Countries
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Central Contacts
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Facility Contacts
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References
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Wang L, Zhang Y, Han D, Wei M, Zhang J, Cheng X, Zhang Y, Shi M, Song Z, Wang X, Zhang X, Su D. Effect of high flow nasal cannula oxygenation on incidence of hypoxia during sedated gastrointestinal endoscopy in patients with obesity: multicentre randomised controlled trial. BMJ. 2025 Feb 11;388:e080795. doi: 10.1136/bmj-2024-080795.
Other Identifiers
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HFNOIO
Identifier Type: -
Identifier Source: org_study_id
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