SubsTRate OxidatioN in Girls

NCT ID: NCT04483921

Last Updated: 2024-04-02

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 14 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2020-07-15
• Study Completion Date: 2023-10-20

Brief Summary

This study will examine race differences in total energy expenditure and respiratory quotient (RQ) during and after exercise, compared to a sedentary control condition, in adolescent girls who are classified as overweight. In addition, subjective appetite and objective energy intake will be measured throughout the assessment periods.

Detailed Description

Aim 1: Measure 24-hour energy expenditure and its components (resting, activity, and sleep energy expenditure) and compare differences between African-American and White girls.

Hypothesis: Total, resting, and sleep energy expenditure will be lower in African-American relative to White girls. Activity energy expenditure will be equivalent per the study design.

Aim 2: Measure and compare substrate oxidation and associations with appetite (i.e., hunger, desire to eat) and energy intake between African-American and White girls.

Hypothesis: African-American girls will have a higher RQ at rest, during exercise, and following exercise, and RQ will be positively associated with subjective appetite ratings and energy intake.

Conditions

Overweight Adolescents

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

Exercise

Participants will complete a prescribed exercise bout.

Group Type: EXPERIMENTAL

Acute exercise

Intervention Type: OTHER

Participants will complete a morning exercise bout at 70% of their individual maximal aerobic capacity to burn 200 kilocalories above their basal metabolic rate.

Sedentary

Participants will rest quietly in a seated position for the equivalent amount of time prescribed for the exercise condition.

Group Type: NO_INTERVENTION

No interventions assigned to this group

Interventions

Acute exercise

Participants will complete a morning exercise bout at 70% of their individual maximal aerobic capacity to burn 200 kilocalories above their basal metabolic rate.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Female
• Age 13-17 years, inclusive
• Achieved menarche based on parent- and/or self-report
• Overweight based on BMI percentile for age and sex (≥ 85th and < 95th)
• Self-identification as non-Hispanic White or African-American
• Willing to maintain current physical activity, sleep schedule, and dietary habits during the study
• Willing to comply with study procedures

Exclusion Criteria

• Contraindications to exercise testing as defined by the American College of Sports Medicine (i.e., medical history of cardiovascular, pulmonary, or physical conditions that affect the ability to exercise)
• Food allergies
• Dietary restrictions
• Unwilling to consume study foods
• History of polycystic ovary syndrome (PCOS)
• Current amenorrhea or other menstrual cycle irregularities
• Pregnant or currently breastfeeding
• Current anemia
• Use of medications affecting metabolism or sleep
• Inability to properly or safely complete the study procedures per the investigators' discretion

• Minimum Eligible Age: 13 Years
• Maximum Eligible Age: 17 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: Yes

Sponsors

Nutrition Obesity Research Center

OTHER

Sponsor Role: collaborator

Pennington Biomedical Research Center

OTHER

Sponsor Role: lead

Responsible Party

Eric Ravussin

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Eric Ravussin, PhD

Role: PRINCIPAL_INVESTIGATOR

Professor

Locations

Pennington Biomedical Research Center

Baton Rouge, Louisiana, United States

Countries

United States

Other Identifiers

PBRC 2020-003

Identifier Type: -

Identifier Source: org_study_id