Effects of a 12-week Combined Exercise Program on Ghrelins in Obese Adolescent Girls

NCT ID: NCT04447391

Last Updated: 2020-06-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-09-10

Study Completion Date

2015-12-31

Brief Summary

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This study aimed to explore the effects of a 12-week combined exercise on ghrelin O acyl transferase, acylated ghrelin and desacylated ghrelin levels in obese girls.

Detailed Description

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Little is known about on ghrelin O acyl transferase (GOAT), acylated ghrelin (AG) and desacylated ghrelin (DAG) levels during long-term exercise in adolescent population. Our previous study showed that combined exercise program in overweight children increases DAG with unchanged AG. This study aimed to explore the effects of a 12-week combined exercise on GOAT, AG, and DAG in obese girls.

Conditions

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Ghrelin

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

DOUBLE

Caregivers Outcome Assessors

Study Groups

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Exercise group

Exercise group who performed a combined exercise and 300 kcal/day deficit diet during 12 weeks.

Group Type EXPERIMENTAL

Combined exercise program

Intervention Type OTHER

Combined exercise programme, consisting of warm-up, aerobic exercise, resistance training, and cool-down, 3 days a week after school for 50 minutes from 17;30 under supervision by a trainer plus 300 kcal deficit diet

Control group

Control group who performed 300 kcal/day deficit diet during 12 weeks.

Group Type PLACEBO_COMPARATOR

Control

Intervention Type OTHER

300 kcal deficit diet only

Interventions

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Combined exercise program

Combined exercise programme, consisting of warm-up, aerobic exercise, resistance training, and cool-down, 3 days a week after school for 50 minutes from 17;30 under supervision by a trainer plus 300 kcal deficit diet

Intervention Type OTHER

Control

300 kcal deficit diet only

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* girls between 16 and 18 years
* being classified as being overweight or obese defined with the 85th percentile of body mass index or above based on the 2007 growth chart for Korean children aged 2-18 years.
* After consultation with a physician, they were required to be considered physically healthy enough to engage in regular exercise after school.

Exclusion Criteria

* participation in any weight-management programme in the past 6 months
* engagement in other exercise programs except for regular physical education at school
* smoking
* amenorrhea for consecutive 2 months or more
* being treated for hereditary diseases, mental disorder, hypertension, diabetes mellitus, or musculoskeletal impairments
* taking any medication or supplements for weight control
Minimum Eligible Age

16 Years

Maximum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Pusan National University Yangsan Hospital

OTHER

Sponsor Role lead

Responsible Party

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Sang Yeoup Lee

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Sang Yeoup Lee, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Pusan National University Yangsan Hospital

Locations

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Pusan National University Yangsan Hospital

Yangsan, Gyeungsangnam-do, South Korea

Site Status

Countries

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South Korea

Other Identifiers

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04-2015-015

Identifier Type: -

Identifier Source: org_study_id

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