Glucose and Lipid Metabolism in Adolescents

NCT ID: NCT00998855

Last Updated: 2011-06-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

42 participants

Study Classification

OBSERVATIONAL

Study Start Date

2004-02-29

Study Completion Date

2011-12-31

Brief Summary

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A 12 wk aerobic exercise program will reduce visceral, hepatic and intramyocellular fat accumulation and improve insulin sensitivity and glucose metabolism in obese sedentary Hispanic adolescents.

Detailed Description

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Lean and Obese post pubertal adolescents perform an aerobic exercise program 30 minx4/week at a heart rate corresponding to at least 70% of that obtained at VO2 peak. The exercise program is preceded and followed by a 7 d diet delivered by the metabolic research kitchen (identical on both study occasions); metabolic studies (identical on both study occasions) including 24h calorimetry, measurements of glucose and lipid metabolism and insulin sensitivity and secretion using compounds labelled with stable i.e. non radioactive isotopes and gas chromatography-mass spectrometry.Fat mass and lean body mass are measured by DXA and visceral/subcutaneous, hepatic and intramyocellular fat by MRI/MRS. Since we want to specifically determine the effects of exercise, there is no intent of weight loss. The subjects are weighed twice a week to assure weight stability.

Conditions

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Exercise Obesity Insulin Sensitivity

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Adolescents

Post pubertal, sedentary lean and obese Hispanic adolescents

Exercise

Intervention Type BEHAVIORAL

12 wk aerobic or/ resistance exercise program

Interventions

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Exercise

12 wk aerobic or/ resistance exercise program

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Healthy
* No medication
* Sedentary
* No first degree relative with diabetes,
* Hispanic
* BMI \>30 or \<25 kg/m2.

Exclusion Criteria

* Any medication including birth control pills
* Performing more than \>45 min of moderate to light physical activity/week
* Chronic illness
Minimum Eligible Age

13 Years

Maximum Eligible Age

17 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Institutes of Health (NIH)

NIH

Sponsor Role lead

Responsible Party

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Baylor College of Medicine, Houston TX

Principal Investigators

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Agneta L Sunehag, M.D., Ph.D

Role: PRINCIPAL_INVESTIGATOR

Baylor College of Medicine

Locations

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Baylor College of Medicine

Houston, Texas, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Agneta L Sunehag, M.D., Ph.D.

Role: CONTACT

713 798 6725

Facility Contacts

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Agneta L Sunehag, M.D., Ph.D

Role: primary

713-798-6725

Other Identifiers

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NIHNICHDRO1 HD044609

Identifier Type: -

Identifier Source: secondary_id

sunehagexercise

Identifier Type: -

Identifier Source: org_study_id

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