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Physical Activity in Youth: Implications for Reversing Risk Factors for Type 2 Diabetes

NCT ID: NCT00739180

Last Updated: 2012-11-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

45 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-11-30

Study Completion Date

2011-10-31

Brief Summary

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In this randomized controlled trial, we will examine the effect of a 3-month exercise training (aerobic exercise versus resistance exercise) without calorie restriction on total and regional adiposity, and risk of type 2 diabetes in overweight children and adolescents.

Detailed Description

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Conditions

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Abdominal Obesity

Keywords

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Childhood obesity Abdominal obesity Visceral fat Insulin resistance Liver fat Skeletal muscle lipid Fitness

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Control

Standard care control

Group Type OTHER

Control

Intervention Type OTHER

Standard care control (no exercise)

Aerobic Exercise

Group Type ACTIVE_COMPARATOR

Aerobic exercise

Intervention Type OTHER

Supervised aerobic exercise using treadmills, bikes, and ellipticals

Resistance Exercise

Group Type ACTIVE_COMPARATOR

Resistance Exercise

Intervention Type OTHER

Supervised resistance exercise using stack weight equipments.

Interventions

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Control

Standard care control (no exercise)

Intervention Type OTHER

Resistance Exercise

Supervised resistance exercise using stack weight equipments.

Intervention Type OTHER

Aerobic exercise

Supervised aerobic exercise using treadmills, bikes, and ellipticals

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Healthy overweight (BMI \>-95th) youth between 12 and 18 years of age
* Waist circumference \>-75th percentile
* Sedentary (no structured exercise \>2 times/week for past 6 months)
* Non-smokers, non-diabetic, no medical conditions
* Weight stable for past 3 months

Exclusion Criteria

* Smokers,
* diabetic,
* psychiatric disorders,
* syndromatic obesity
Minimum Eligible Age

12 Years

Maximum Eligible Age

18 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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American Diabetes Association

OTHER

Sponsor Role collaborator

University of Pittsburgh

OTHER

Sponsor Role lead

Responsible Party

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SoJung Lee

Assistant Professor of Pediatrics

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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SoJung Lee, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Pittsburgh

Locations

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Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine

Pittsburgh, Pennsylvania, United States

Site Status

Countries

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United States

References

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Yu WW, Lee S, Arslanian S, Tamim H, Kuk JL. Effects of Exercise on Resting Metabolic Rate in Adolescents with Overweight and Obesity. Child Obes. 2021 Jun;17(4):249-256. doi: 10.1089/chi.2020.0280. Epub 2021 Mar 18.

Reference Type DERIVED
PMID: 33739874 (View on PubMed)

Kuk JL, Lee S. Assessing the utility of cardiorespiratory fitness, visceral fat, and liver fat in predicting changes in insulin sensitivity beyond simple changes in body weight after exercise training in adolescents. Appl Physiol Nutr Metab. 2021 Jan;46(1):55-62. doi: 10.1139/apnm-2020-0284. Epub 2020 Jul 16.

Reference Type DERIVED
PMID: 32674604 (View on PubMed)

Kuk JL, Lee S. Sex and Ethnic Differences in the Relationship between Changes in Anthropometric Measurements and Visceral Fat in Adolescents with Obesity. J Pediatr. 2019 Oct;213:121-127. doi: 10.1016/j.jpeds.2019.05.052. Epub 2019 Jun 22.

Reference Type DERIVED
PMID: 31235380 (View on PubMed)

Other Identifiers

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7-08-JF-27

Identifier Type: -

Identifier Source: org_study_id