Effects of Resistance Training on Substrate Metabolism During the Menstrual Cycle

NCT ID: NCT04024826

Last Updated: 2021-10-04

Basic Information

• Recruitment Status: TERMINATED
• Clinical Phase: NA
• Total Enrollment: 10 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2019-07-01
• Study Completion Date: 2020-03-16

Brief Summary

This research project's objective is to investigate substrate metabolism behavior in response to the RT during different phases of the menstrual cycle.

Detailed Description

Based on the literature the investigators hypothesize an increase in fat oxidation in early follicular phase(EFP) and late follicular phase (LFP) when compared to early luteal phase (ELP) and late luteal phase (LLP). Given the lack of research in exercise and menstrual cycle - especially in resistance training - results are uncertain unless the investigators base their hypotheses only on the general physiological effects of sex hormones (without exercise). In this case, the investigators expect to see a reduced carbohydrate utilization and an increased utilization of fats in EFP and LFP. In addition, the intervention is focused on muscular endurance and, therefore, it is expected to see a higher reliance on aerobic pathways. It is expected that the effects of the intervention will be added to the effects of estrogens, with increasing fat oxidation when estrogen levels are higher. Lastly, a comparison of fat oxidation levels obtained on each sub-phase would reveal if there are differences in the magnitude of the effect of distinct concentrations of estrogen and progesterone.

Conditions

Menstrual Cycle; Substrate Metabolism

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

Early Follicular Phase (EFP)

This group is comprised of participants at the Early Follicular Phase (EFP) of the menstrual cycle.

Group Type: EXPERIMENTAL

EFP

Intervention Type: BEHAVIORAL

This group will perform the Resistance training intervention on day 4 of the menstrual cycle, which corresponds to the mid of early follicular phase.

Late Follicular Phase

This group is comprised of participants at the Late Follicular Phase (LFP) of the menstrual cycle.

Group Type: EXPERIMENTAL

LFP

Intervention Type: BEHAVIORAL

This group will perform the Resistance training intervention on day 11 of the menstrual cycle, which corresponds to the mid of late follicular phase.

Early Luteal Phase

This group is comprised of participants at the Early Luteal Phase (ELP) of the menstrual cycle.

Group Type: EXPERIMENTAL

ELP

Intervention Type: BEHAVIORAL

This group will perform the Resistance training intervention on the day 18 of the menstrual cycle, which corresponds to the mid of early luteal phase

Late Luteal Phase

This group is comprised of participants at the Late Luteal Phase(LLP) of the menstrual cycle.

Group Type: EXPERIMENTAL

LLP

Intervention Type: BEHAVIORAL

This group will perform the Resistance training intervention on day 21 of the menstrual cycle, which corresponds to the mid of late luteal phase

Interventions

EFP

This group will perform the Resistance training intervention on day 4 of the menstrual cycle, which corresponds to the mid of early follicular phase.

Intervention Type: BEHAVIORAL

LFP

This group will perform the Resistance training intervention on day 11 of the menstrual cycle, which corresponds to the mid of late follicular phase.

Intervention Type: BEHAVIORAL

ELP

This group will perform the Resistance training intervention on the day 18 of the menstrual cycle, which corresponds to the mid of early luteal phase

Intervention Type: BEHAVIORAL

LLP

This group will perform the Resistance training intervention on day 21 of the menstrual cycle, which corresponds to the mid of late luteal phase

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• Females with BMI-18.5-34.99 and between 18-45 years, with normal menstrual cycle defined as 28-30 days cycles +-3 days.
• Including higher BMI participants might alter the results as increased body fat has been linked to changes in different hormonal levels (not only sex hormones) and that might influence substrate utilization.
• Sedentary .or physically active for 2 days a week or less.

Exclusion Criteria

• • Musculoskeletal injuries,

• cardio-respiratory conditions,
• metabolic conditions,
• irregular menstrual cycle,
• menstrual dysfunction or unusual sex hormone levels,
• on contraceptives,
• on medication that alter hormonal or cardio-respiratory responses,
• pre-menopausal symptoms,
• on moderate to high-intensity exercise regime more than 2d/week.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 45 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: Yes

Sponsors

Southern Illinois University Edwardsville

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Maria Fernandez del Valle, PhD

Role: PRINCIPAL_INVESTIGATOR

Southern Illinois University Edwardsville

Locations

Southern Illinois University Edwardsville

Edwardsville, Illinois, United States

Countries

United States

Other Identifiers

111A

Identifier Type: -

Identifier Source: org_study_id