Orally Administered ENT-01 for Parkinson's Disease-Related Constipation Follow-on Safety "Roll-over" Study (Rollover)

NCT ID: NCT04483479

Last Updated: 2024-03-19

Basic Information

• Recruitment Status: TERMINATED
• Clinical Phase: PHASE2
• Total Enrollment: 27 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2020-07-30
• Study Completion Date: 2022-02-17

Brief Summary

This study will be conducted as an open-label safety follow-on to a multi-center, double-blind, randomized study. All subjects who participated in the randomized study will be offered participation in this unblinded, single-arm, safety study. Approximately 50 subjects will be entered into the study and ENT-01 will be administered daily in escalating doses followed by a fixed dose for 12 weeks. Each subject will participate for approximately 20 weeks; dosing duration will be approximately 14 weeks.

Detailed Description

The study will be conducted on an out-patient or in-patient basis with visits performed at the screening visit, at 6 and 12 weeks, and at the end of the 6th week of the wash-out period (end of study).

The dose escalation period will last up to 20 days, the fixed dose period will last 12 weeks, and the wash-out period will last 6 weeks.

Subjects will begin dosing at the same dose level they were stratified to in the ENT-01-030 randomized study (i.e., starting at either 3 tablets or 6 tablets,) and escalate up to a pro-kinetic dose or a maximum dose of 250mg.

Conditions

Parkinson Disease; Constipation

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Active Treatment

Orally Administered ENT-01 25mg Tablet Once Daily (Dose dependent on ENT-01-030 dose level stratification)

Group Type: EXPERIMENTAL

Active Investigational Treatment ENT-01

Intervention Type: DRUG

ENT-01 will be administered in tablet form, once daily in escalating doses followed by a fixed-dose for 12 weeks.

Interventions

Active Investigational Treatment ENT-01

ENT-01 will be administered in tablet form, once daily in escalating doses followed by a fixed-dose for 12 weeks.

Intervention Type: DRUG

Other Intervention Names

ENT-01

Eligibility Criteria

Inclusion Criteria

1. All subjects who participated in the randomized study ENT-01-030 (KARMET Stage 2 Extension subjects) and who completed the dosing period.

2. Subjects aged 30-90 years at the time of screening for the ENT-01-030 study, both genders

3. Subjects must provide informed consent and be willing and able to comply with study procedures.

4. Subjects must be able to read, understand, and accurately record data into the diary to guarantee full participation in the study.

5. Female subjects must have negative serum or urine pregnancy tests and must not be lactating. For females able to bear children, a hormonal (i.e., oral, implantable, or injectable) and single-barrier method, or a double-barrier method of birth control must be used throughout the study. A vasectomized partner will be allowed as one in conjunction with another single-barrier method.

6. Female subjects unable to bear children must have this documented in the CRF (i.e., tubal ligation, hysterectomy, or postmenopausal [defined as a minimum of one year since the last menstrual period]). Post-menopausal status will be confirmed by follicle stimulating hormone (FSH) in women less than 60 years of age.

Exclusion Criteria

1. Unable or unwilling to provide informed consent or to comply with study procedures.

2. Unable to withdraw proton pump inhibitors.

3. Unable or unwilling to withdraw from laxatives, opiates, clonazepam, or any medications which may cause constipation 2 weeks prior to the dose adjustment period and throughout the rest of the study.

4. Diagnosis of secondary constipation beyond that of Parkinson's disease.

5. A compromised gastrointestinal system which includes:

• Structural, metabolic, or functional GI diseases or disorders.
• Acute GI illness within 2 weeks of the screening visit.
• History of major GI surgery within 30 days of the screening visit (a history of cholecystectomy, polypectomy, hernia repair or appendicectomy are not exclusionary as long as they were performed more than 30 days before the screening visit).

6. Neurological disorder other than Parkinson's disease that in the opinion of the investigator might interfere with the conduct of the study.

7. On treatment with intra-jejunal dopamine or carbidopa/levodopa (i.e. Duopa).

8. Subjects starting a new Parkinson's disease medication or modifying an existing medication within 2 weeks prior to enrollment.

9. Unable to maintain a stable diet regimen.

10. Subjects with a cognitive impairment that preclude them from understanding the informed consent.

11. Subjects placed under legal guardianship.

12. History of excessive alcohol use or substance abuse.

13. Any clinically significant abnormalities on screening laboratories or physical examination requiring further evaluation or treatment.

14. Females who are pregnant or breastfeeding.

15. Subject or caregiver unable to administer daily oral dosing of study drug.

16. Participation in a non-Enterin investigational drug trial within the month prior to dosing in the present study.

17. Any other reason, which in the opinion of the investigator would confound proper interpretation of the study.

• Minimum Eligible Age: 30 Years
• Maximum Eligible Age: 90 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Enterin Inc.

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Michael Zasloff, MD, PhD

Role: STUDY_CHAIR

Enterin Inc.

Denise Barbut, MD, FRCP

Role: STUDY_DIRECTOR

Enterin Inc.

Locations

The Parkinson's and Movement Disorder Institute

Fountain Valley, California, United States

SC3 Research - Pasadena

Pasadena, California, United States

Rocky Mountain Movement Disorders Center

Englewood, Colorado, United States

Georgetown Universtiy, Department of Neurology

Washington D.C., District of Columbia, United States

JEM Research Institute

Atlantis, Florida, United States

Parkinson's Disease and Movement Disorders Center of Boca Raton

Boca Raton, Florida, United States

Parkinson's Disease Treatment Center of SWFL

Port Charlotte, Florida, United States

Intercoastal Medical Group

Sarasota, Florida, United States

USF Health Byrd Parkinson's Disease Movement Disorders Center of Excellence

Tampa, Florida, United States

Premiere Research Institute at Palm Beach Neurology

West Palm Beach, Florida, United States

Dartmouth Hitchcock Medical Center

Lebanon, New Hampshire, United States

Albany Medical College

Albany, New York, United States

Icahn School of Medicine at Mount Sinai

New York, New York, United States

Cleveland Clinic

Cleveland, Ohio, United States

University of Toledo Medical Center

Toledo, Ohio, United States

Penn State University

Hershey, Pennsylvania, United States

Evergreen Health - Booth Gardner Parkinson's Care Center

Kirkland, Washington, United States

University Physicians & Surgeons, Inc. dba Marshall Health

Huntington, West Virginia, United States

Countries

United States

Provided Documents

Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

ENT-01-2b-20-02

Identifier Type: -

Identifier Source: org_study_id