Pupillary Response to Incremental Tetanic Stimulations Under Propofol-remifentanil TCI
NCT ID: NCT04465773
Last Updated: 2020-07-10
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
18 participants
INTERVENTIONAL
2012-01-31
2013-07-31
Brief Summary
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Detailed Description
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Anesthetic protocol: 10 minutes of steady-state general anesthesia (before extubation during a scheduled gynecological surgery) with remifentanil target concentration of 1 ng/ml, and propofol target concentration adjusted to maintain bispectral index between 45 and 55.
Study period: 6 tetanic stimulations of incremental intensities were applied to the patients: 10, 20, 30, 40, 50, 60 milliamps Pupillary dilation in response to these stimulations was recorded.
Then, propofol and remifentanil infusions were discontinued, and patients were extubated.
Conditions
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Study Design
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NA
SINGLE_GROUP
DIAGNOSTIC
NONE
Study Groups
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pupillometry
General anesthesia for scheduled gynecological surgery Propofol target concentration adjusted to maintain bispectral index between 45 and 55 for 10 minutes Remifentanil target concentration 1 ng/ml for 10 minutes Tetanic stimulations of 10-20-30-40-50-60 milliamps (5 seconds per stimulation, 2 minutes between stimulations) Continuous pupillometry VideoAlgesiGraph
general anesthesia for scheduled gynecological surgery
Propofol
continuous infusion, target concentration adjusted to maintain bispectral index between 45 and 55
Remifentanil, Ultiva®
continuous infusion, target concentration 1 ng/ml
tetanic stimulations
10-20-30-40-50-60 milliamps, 5 seconds, 100 Hertz 2 minutes between stimulations delivered via the standard neuromuscular blocking agents monitor
VideoAlgesiGraph
non invasive infrared camera placed in front of the left eye of the patients during the study period, connected to a laptop. No part of the device touches the eye.
Interventions
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general anesthesia for scheduled gynecological surgery
Propofol
continuous infusion, target concentration adjusted to maintain bispectral index between 45 and 55
Remifentanil, Ultiva®
continuous infusion, target concentration 1 ng/ml
tetanic stimulations
10-20-30-40-50-60 milliamps, 5 seconds, 100 Hertz 2 minutes between stimulations delivered via the standard neuromuscular blocking agents monitor
VideoAlgesiGraph
non invasive infrared camera placed in front of the left eye of the patients during the study period, connected to a laptop. No part of the device touches the eye.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* written informed consent
Exclusion Criteria
* neurologic disease
* preoperative chronic pain or pain medication
* medication interfering with autonomous nervous system (beta blockers, alpha agonists, metoclopramide, droperidol, atropine, catecholamines)
18 Years
65 Years
FEMALE
No
Sponsors
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Pr Isabelle CONSTANT
OTHER
Responsible Party
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Pr Isabelle CONSTANT
Professor
Locations
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Departement d'anesthesie Hopital Armand Trousseau
Paris, , France
Countries
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Other Identifiers
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Pupillo propofol remi stim
Identifier Type: -
Identifier Source: org_study_id
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