Influence of Depth of Anesthesia on Pupillary Reactivity to a Standardized Stimulus
NCT ID: NCT02595476
Last Updated: 2017-04-04
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
12 participants
INTERVENTIONAL
2015-01-31
2016-03-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
NONE
Study Groups
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BIS 55
1. Induction:
TCI propofol (6 µg/ml) - remifentanil (4 ng/ml) Atracurium IV (0.5 mg/kg)
2. Orotracheal Intubation
3. Remifentanil target decreased to 1 ng/ml
4. Propofol target adjustment to reach BIS 55
5. 10 minutes steady state
6. Tetanic stimulation (ulnar nerve): 100 Hz, 60 milliamps, 5 seconds
7. Pupillary dilation recording (videopupillometer Algiscan)
Remifentanil
propofol
TCI
Tetanic stimulation
Algiscan
Pupillometry
BIS 25
1. Induction:
TCI propofol (6 µg/ml) - remifentanil (4 ng/ml) Atracurium IV (0.5 mg/kg)
2. Orotracheal Intubation
3. Remifentanil target decreased to 1 ng/ml
4. Propofol target adjustment to reach BIS 25
5. 10 minutes steady state
6. Tetanic stimulation (ulnar nerve): 100 Hz, 60 milliamps, 5 seconds
7. Pupillary dilation recording (videopupillometer Algiscan)
Remifentanil
propofol
TCI
Tetanic stimulation
Algiscan
Pupillometry
Interventions
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Remifentanil
propofol
TCI
Tetanic stimulation
Algiscan
Pupillometry
Eligibility Criteria
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Inclusion Criteria
* scheduled for an idiopathic scoliosis surgical correction
Exclusion Criteria
* Neurologic or muscular pathology
* Metabolic pathology
* Chronic pain
10 Years
20 Years
ALL
No
Sponsors
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Hôpital Armand Trousseau
OTHER
Responsible Party
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Pr Isabelle CONSTANT
Professor Isabelle COnstant
Principal Investigators
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Isabelle Constant, MD, PHD
Role: STUDY_DIRECTOR
Hopital Armand Trousseau
Locations
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Departement d'anesthesie Hopital Armand Trousseau
Paris, , France
Countries
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References
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Sabourdin N, Peretout JB, Khalil E, Guye ML, Louvet N, Constant I. Influence of Depth of Hypnosis on Pupillary Reactivity to a Standardized Tetanic Stimulus in Patients Under Propofol-Remifentanil Target-Controlled Infusion: A Crossover Randomized Pilot Study. Anesth Analg. 2018 Jan;126(1):70-77. doi: 10.1213/ANE.0000000000001802.
Other Identifiers
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Anesthésie Trousseau 002
Identifier Type: -
Identifier Source: org_study_id
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