Bispectral Index (BIS) Values Required for an Adequate Depth of Anesthesia in Elderly Patients Using Propofol

NCT ID: NCT03195530

Last Updated: 2018-04-11

Basic Information

• Recruitment Status: TERMINATED
• Total Enrollment: 12 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2017-05-01
• Study Completion Date: 2018-03-31

Brief Summary

A correlation between the bispectral index values and electroencephalographic patterns at the loss of consciousness (LOC) when using propofol in elderly patients, has not been determined.

Our aim is to describe the BIS values and the power of the alpha band in the electroencephalography in elderly patients, at the LOC moment.

Detailed Description

Propofol is an anesthetic drug regularly used in elderly patients requiring anesthesia. The electroencephalographic pattern recognized when propofol is administered, is different to the pattern obtained in younger patients. Both groups presents an alpha and slow bands, but they differ in the intensity of the signal. Younger patients presents more intense electroencephalographic bands than older patients.

Bispectral index (BIS) is a clinical indicator used to evaluate the depth of anesthesia. A correlation between this indicator and the power of electroencephalographic bands has not been determined.

We will describe the LOC moment of elderly patients receiving propofol as anesthetic for general surgery, with the EEG characteristic bands and the BIS value obtained at that moment. The BIS values related to the EEG characteristic bands can be described, to correlate the actual indicators of depth of anesthesia with new parameters.

Conditions

Anesthesia

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Elderly patients

Patients over 65 years, scheduled to general surgery, requiring general anesthesia

Propofol

Intervention Type: DRUG

Induction of anesthesia using propofol, and recording the BIS values and EEG patterns during the induction

Interventions

Propofol

Induction of anesthesia using propofol, and recording the BIS values and EEG patterns during the induction

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Patients over 65 years
• Scheduled for elective surgery requiring general anesthesia
• American Society of Anesthesiology (ASA) Score I or II

Exclusion Criteria

• Patients with neurological diseases
• Requiring the use of two or more drugs affecting Central nervous system
• History of drugs or alcohol abuse
• Body mass index over 35 kg/m^2
• Propofol allergy
• Cardiac congestive failure
• History of coronary syndrome
• Minimental test altered (Score under 24 points)

• Minimum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Pontificia Universidad Catolica de Chile

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Division de Anestesia - Pontificia Universidad Catolica de Chile

Santiago, Santiago Metropolitan, Chile

Countries

Chile

Other Identifiers

161207002

Identifier Type: -

Identifier Source: org_study_id