Artificial Induction of Labour in Full-term Singleton Pregnancy : Comparative Randomized Trial of Two Strategies

NCT ID: NCT04452747

Last Updated: 2023-05-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

450 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-11-16

Study Completion Date

2023-03-01

Brief Summary

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Labour induction is an obstetrical procedure, which artificially starts the process of cervix dilation, in order to induce labour. Several methods of labour induction exist : mechanical ones (using dilatation balloons) or pharmacological ones (using prostaglandins or oxytocin). This trial aims to compare, in case of non-favourable cervix, the strategy of labour induction using the Propess® method first (Dino-first) versus the strategy beginning with the use of a dilatation balloon (Ballon-first), with respect of the usual practice and the current guidelines.

Detailed Description

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Conditions

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Pregnancy Related

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

NONE

Study Groups

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Dino-first

Labour will be induced by the use of the vaginal Dinoprostone system (Propess®) first.

Group Type ACTIVE_COMPARATOR

Vaginal Dinoprostone system (Propess®)

Intervention Type PROCEDURE

Labour will be induced using the vaginal Dinoprostone system (Propess®) as a first strategy

Balloon-first

Labour will be induced by the use of a cervix dilatation balloon first.

Group Type ACTIVE_COMPARATOR

Dilatation balloon

Intervention Type PROCEDURE

Labour will be induced using a cervix dilatation balloon as a first strategy

Interventions

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Vaginal Dinoprostone system (Propess®)

Labour will be induced using the vaginal Dinoprostone system (Propess®) as a first strategy

Intervention Type PROCEDURE

Dilatation balloon

Labour will be induced using a cervix dilatation balloon as a first strategy

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Women with singleton pregnancy
* Fetus with cephalic presentation
* Intact membranes between 37 and 42 weeks of amenorrhea
* Medical indication for labour induction according to the "Haute Autorité de Santé" (HAS) guidelines
* Unfavourable cervix (Bishop scoring \< 7)
* Age \> 18 years-old
* Person affiliated to a healthcare system
* Good understanding of the French language

Exclusion Criteria

* Previous C-section or uterine incision
* Placenta previa
* Metrorrhagia of unknown origin
* Lethal foetal abnormality
* Hyperreactivity to one of the molecules used for the induction (dinoprostone or oxytocin) or to latex
* Subject participants to another biomedical research
* Subject under legal guardianship or curatorship
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Montpellier

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Florent FUCHS, MD PhD

Role: STUDY_DIRECTOR

UH of Montpellier

Locations

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Montpellier University Hospital

Montpellier, , France

Site Status

Nimes University Hospital

Nîmes, , France

Site Status

Countries

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France

Other Identifiers

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7756

Identifier Type: OTHER

Identifier Source: secondary_id

RECHMPL19_0044

Identifier Type: -

Identifier Source: org_study_id

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