Sylvatic Transmission of Zika, Dengue, and Chikungunya Viruses in Thailand and Cambodia

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

View full results

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-02-08

Study Completion Date

2021-05-07

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Background:

Zika, dengue, and chikungunya are spread by mosquitos. These diseases have a major impact on public health. This is especially true in in Southeast Asia. Non-human primates (such as macaques) could play an essential role in spreading these diseases. Researchers want to further understand the relationship between humans and these primates. They want to see how this affects how mosquito-borne viruses are spread in Southeast Asia.

Objective:

To describe the prevalence of Zika virus, dengue virus, and chikungunya virus in the blood of people who live close to long-tailed macaques in Thailand and Cambodia.

Eligibility:

Healthy people aged 18-55 who have lived or worked within approximately 10 kilometers of the Wat Amphae Phnom monkey habitat in Kampong Speu, Cambodia, for a minimum of 2 years

Design:

Participation will last 1 day.

Participants will be screened in person through an interview. Their medical history will be reviewed.

Participants will give information about themselves. This will include sex, age, and behaviors related to the spread of mosquito-borne disease. For example, they will be asked about the number of water containers at their home. They will be asked about recent travel. They will be asked about the extent of their contact with the macaques.

Participants will give a blood sample....

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Investigating Vector-Borne Determinants of Aedes Transmitted Arboviral Infections in Cambodia: An Observational Longitudinal Cohort Study in Children

NCT03534245

Dengue Fever

COMPLETED

Febrile Disease Landscape in Cambodia Via Metagenomic Pathogen Sequencing

NCT04034264

Vector-Borne Diseases Emerging Pathogens

RECRUITING

The Evaluation of Potential Zika, Chikungunya, and Dengue Infections in Mexico

NCT02831699

Zika Virus Disease (Disorder) Dengue Chikungunya

COMPLETED

Virological and Immunological Determinants of Arbovirus Infection in New Caledonia

NCT04619823

Arbovirus Infections Zika Dengue +1 more

RECRUITING NA

Factors Associated With Hospitalization and Severity of Arbovirosis in the Indian Ocean

NCT07119086

Arbovirus Disease

RECRUITING NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Arboviral epidemics continue to emerge suddenly and spread of disease is unpredictable. The 2015-16 Zika epidemic resulted in a high case number in Thailand, but not in neighboring Cambodia. It is known that nonhuman primates (NHPs) are important reservoirs of arboviruses, but the importance of their epidemiological role in the transmission of arboviruses is not clearly understood. While transmission dynamics are complex and require consideration of many variables, primate reservoirs are not routinely sampled, particularly in Southeast Asia, because of the level of operational complexity and skill required.

Here, we propose a serological survey for evidence of Zika virus (ZIKV), dengue virus (DENV), and chikungunya virus (CHIKV) exposure in long-tailed macaques and human adults who live or work in close proximity to these monkeys in Thailand and Cambodia. We hypothesize that ZIKV seroprevalence in both humans and macaques will be higher in Thailand than Cambodia. With the current rise of arboviral diseases around the world, we hope the results of this study contribute to better understanding of the epidemiology and burden of arboviral diseases in this region.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Dengue Fever Zika Vector-Borne Diseases Chikungunya

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

1

Healthy Cambodian Adults aged 18-55 were screened for antibodies to ZIKV, DENV, and CHIKV at a single time point at Amphae Phnom, Chbar Mon, Cambodia.

No interventions assigned to this group

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

In order to be eligible to participate in this study, an individual must meet all of the following criteria:

1. Provision of signed and dated ICF
2. Able to provide informed consent
3. Stated willingness to comply with study procedures
4. Male or female, aged 18-55 years
5. Live/work within approximately 10 km of the Wat Amphae Phnom monkey habitat for minimum of 2 years
6. In good general health as evidenced by screening medical history
7. Willing to allow biological samples to be stored for future research

Exclusion Criteria

1\. Any underlying, chronic, or current medical condition that, in the opinion of the investigator, would interfere with participation in the study (e.g., inability or great difficulty in drawing blood)

Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No