Iliac Crest Bone Graft Harvesting for Pediatric Pelvic Osteotomy

NCT ID: NCT04425369

Last Updated: 2020-06-11

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 47 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2015-01-01
• Study Completion Date: 2020-01-01

Brief Summary

The iliac crest is one of the most commonly used bone graft sources, especially in pediatric pelvic osteotomy operations for developmental dysplasia of the hip (DDH) and Legg-Calve-Perthes disease. In this study, we aimed to identify the effects of inner side and two-sided approaches for iliac crest bone harvesting on post-surgery ilium growth in children.

Detailed Description

Autogenous bone grafting is still the gold standard and most effective method for treatment of non-union and bone defects due to congenital disease and infection. Despite the development of bone engineering, none of the allogeneic bone products can match the osteoinductive, osteoconductive, and immunogenic properties of autogenous bone. The iliac crest is one of the most harvested sites other than the fibula, ribs, and ulna. An iliac crest bone graft (ICBG) can supply a larger amount of cortical and cancellous bone than grafts from other donor sites. Pelvic osteotomy is widely used for treating developmental dysplasia of the hip (DDH) and Legg-Calve-Perthes disease. Tricortical structural bone such as that in the ilium is needed to stabilize the pelvis after osteotomy, and the anterior and posterior iliac crest are the two most used graft donor sites. When surgery is planned in the prone position, such as that for posterior spinal fusion, surgeons generally prefer to adopt the posterior approach for ICBG procedures. In supine position surgeries such as pelvic osteotomy for DDH or Legg-Calve-Perthes disease, surgeons prefer the anterior approach for ICBG procedures. There are many studies on iliac bone growth and complications after ICBG procedures. Most of the studies demonstrated good outcomes and few complications. However, according to our literature review, none of the previous studies used the iliac bone for transplantation in pelvic osteotomy. In this study, we compared the results between an inner table harvest site and an inner-outer table harvest site for ICBG used to maintain stability in pelvic osteotomy.

Conditions

Child; Osteotomy

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: DOUBLE

Study Groups

inner side approaches for iliac crest bone graft

An anterior approach was used to expose the inner table of the ilium.

Group Type: NO_INTERVENTION

No interventions assigned to this group

two-sided approaches for iliac crest bone graft

both sides of the ilium were totally exposed of the ilium.

Group Type: EXPERIMENTAL

two-sided approaches for iliac crest bone graft

Intervention Type: PROCEDURE

Only one side of the ilium was exposed when surgery.

Interventions

two-sided approaches for iliac crest bone graft

Only one side of the ilium was exposed when surgery.

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

• the patients who performed iliac crest bone graft and pelvic osteotomy at the same time

Exclusion Criteria

• they had a history of pelvic osteotomy or iliac crest bone graft surgery, bilateral hip disease or congenital bone dysplasia, or were lost to follow-up.

• Minimum Eligible Age: 2 Years
• Maximum Eligible Age: 16 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Yuxi Su

OTHER

Sponsor Role: lead

Responsible Party

Yuxi Su

Vice professor

Responsibility Role: SPONSOR_INVESTIGATOR

Locations

Children's Hospital of Chongqing Medical University

Chongqing, Chongqing Municipality, China

Countries

China

Other Identifiers

CQMU20200017

Identifier Type: -

Identifier Source: org_study_id