Role of the Environment and Endocrine Disruptors in Child Cryptorchidism

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

1452 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-04-16

Study Completion Date

2028-04-15

Brief Summary

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Cryptorchidism is the most frequent congenital defect of the male newborn. It requires surgery in childhood, increases the risk of fertility disorders and cancer. As a major public health objective, it's the subject of numerous recommendations. Its frequency is increasing in some countries faster than a single genetic cause could not explain it. It may occurs in a geographic cluster. The cause of cryptorchidism involves genetic, hormonal and environmental factors. Animal studies suggest that endocrine disruptors interfere with fetal testicular migration. The aim of the study is to find out if some environmental exposition may be associated with cryptorchidism.

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Detailed Description

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Cryptorchidism is the most frequent congenital defect of the male newborn. It requires surgery in childhood, increases the risk of fertility disorders and cancer. As a major public health objective, it's the subject of numerous recommendations. Its frequency is increasing in some countries faster than a single genetic cause could not explain it. It may occurs in a geographic cluster. The cause of cryptorchidism involves genetic, hormonal and environmental factors. Animal studies suggest that endocrine disruptors interfere with fetal testicular migration. The aim of the study is to find out if some environmental exposition may be associated with cryptorchidism.

Conditions

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Cryptorchidism

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Parent of patient with cryptorchidism

parent exposition of endocrine disruptors

Measure of the exposure of parent of male with /without cryptorchidism to endocrine disruptors

Intervention Type OTHER

Measure of the exposure of parent of patient with/without cryptorchidism to endocrine disruptors (job exposure, during pregnancy)

Parent of patient without cryptorchidism

Parent exposition of endocrine disruptors

Measure of the exposure of parent of male with /without cryptorchidism to endocrine disruptors

Intervention Type OTHER

Measure of the exposure of parent of patient with/without cryptorchidism to endocrine disruptors (job exposure, during pregnancy)

Interventions

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Measure of the exposure of parent of male with /without cryptorchidism to endocrine disruptors

Measure of the exposure of parent of patient with/without cryptorchidism to endocrine disruptors (job exposure, during pregnancy)

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

\- Parents of male children from the neonatal period to 18 years of age (during surgery) with cryptorchidism

Exclusion Criteria

* Parents of children without endocrine disease. (adrenal, hypothalamic-pituitary, phosphocalcic, thyroid, diabetes, etc.)
* Parents of children without an associated genital or urinary defect (hypospadias, micropenis, renal and bladder abnormalities)
* Testicular Ectopia (testis outside of normal migration path)
* Anorchidism and evanescent testicles, united or bilateral
* Abnormalities of the abdominal wall (laparoschisis, omphalocele, Prune Belly)
* Cryptorchidism integrating in the context of a polymalformative syndrome, including neurological.

Minimum Eligible Age

1 Month

Maximum Eligible Age

18 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No