Glucose Metabolism After Partial Pancreatectomy

NCT ID: NCT04409171

Last Updated: 2020-06-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

224 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-09-01

Study Completion Date

2020-01-31

Brief Summary

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This is a single center observational study to assess alteration of glucose metabolism after pancreatectomy.

Detailed Description

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Biochemical markers of glucose metabolism including oral glucose tolerance tests, fasting blood glucose, insulin, glucagon and HbA1c were performed on patients receiving pancreatectomy (pancreaticoduodenectomy and distal pancreatectomy). Tests were done preoperatively, postoperatively at 3 months, and at 1 year. The primary endpoints were the incidence and risk factors of new-onset and worsened DM after each type of pancreatectomy.

Conditions

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Pancreatectomy; Hyperglycemia Diabete Mellitus

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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PD

pancreaticoduodenectomy

oral glucose tolerance test

Intervention Type DIAGNOSTIC_TEST

DP

distal pancreatectomy

oral glucose tolerance test

Intervention Type DIAGNOSTIC_TEST

Interventions

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oral glucose tolerance test

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* partial pancreatectomy

Exclusion Criteria

* total pancreatectomy
* incomplete testing
* follow-up loss
* death within 1 year
Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Seoul National University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Yoo-Seok Yoon

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

References

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Lee BW, Kang HW, Heo JS, Choi SH, Kim SY, Min YK, Chung JH, Lee MK, Lee MS, Kim KW. Insulin secretory defect plays a major role in the development of diabetes in patients with distal pancreatectomy. Metabolism. 2006 Jan;55(1):135-41. doi: 10.1016/j.metabol.2005.08.005.

Reference Type BACKGROUND
PMID: 16324932 (View on PubMed)

Hwang HK, Park J, Choi SH, Kang CM, Lee WJ. Predicting new-onset diabetes after minimally invasive subtotal distal pancreatectomy in benign and borderline malignant lesions of the pancreas. Medicine (Baltimore). 2017 Dec;96(51):e9404. doi: 10.1097/MD.0000000000009404.

Reference Type BACKGROUND
PMID: 29390555 (View on PubMed)

Other Identifiers

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SNUBH-GS-HBP6

Identifier Type: -

Identifier Source: org_study_id

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