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Usage of Multiple Drugs in Treatment of Postoperative Vomiting After Laparoscopic Appendectomy

NCT ID: NCT04403191

Last Updated: 2020-05-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

240 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-03-10

Study Completion Date

2020-02-10

Brief Summary

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To compare and evaluate the antiemetic effect and the safety of ondansetron, inhalational isopropyl alcohol and super hydration on adult patients after laparoscopic appendectomy.

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Detailed Description

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This prospective double-blind study done on 240 patients admitted to surgical I.C.U after laparoscopic appendectomy. Those who had preoperative Koivuranta vomiting score of more than 3 enrolled in our study. Every group contains 80 patients. Patients of group A received ondansetron 4 mg intravenous immediately once reached to I.C.U and another same dose after 6 hours while patients of group B received isopropyl alcohol 70% inhalation every 15 min for 4 times then repeated after 6 hours. The last group C received intravenous normal saline at rate of 20 ml/kg over 30 minute and repeated by the same dose after 6 hours. The duration of the study was 24 hours post-operatively. As PONV is self-limited within 24 hours.

Conditions

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to Treat the Vomiting Frequently Occur Post-laparoscopic by Different Anti Emetic Drugs

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Group A

received ondansetron 4 mg intravenous immediately once reached to I.C.U and another same dose after 6 hours

Ondansetron

Intervention Type DRUG

ondansetron 4 mg intravenous immediately once reached to I.C.U and another same dose after 6 hours while patients of group

laparoscopic appendectomy

Intervention Type PROCEDURE

all patients received post operatively after laparoscopic appenectomy

Group B

received isopropyl alcohol 70% inhalation every 15 min for 4 times then repeated after 6 hours

isopropyl alcohol 70% inhalation

Intervention Type DRUG

inhalation every 15 min for 4 times then repeated after 6 hours

laparoscopic appendectomy

Intervention Type PROCEDURE

all patients received post operatively after laparoscopic appenectomy

Group C

received intravenous normal saline at rate of 20 ml/kg over 30 minute and repeated by the same dose after 6 hours.

laparoscopic appendectomy

Intervention Type PROCEDURE

all patients received post operatively after laparoscopic appenectomy

Interventions

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Ondansetron

ondansetron 4 mg intravenous immediately once reached to I.C.U and another same dose after 6 hours while patients of group

Intervention Type DRUG

isopropyl alcohol 70% inhalation

inhalation every 15 min for 4 times then repeated after 6 hours

Intervention Type DRUG

laparoscopic appendectomy

all patients received post operatively after laparoscopic appenectomy

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

postoperative nausea and vomiting

Exclusion Criteria

systemic disease as diabetes or hypertension local gastric diseases
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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King Abdul Aziz Specialist Hospital

NETWORK

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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King abd el Aziz specialist hospital

Ta'if, , Saudi Arabia

Site Status

Countries

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Saudi Arabia

Other Identifiers

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ICU-10-20

Identifier Type: -

Identifier Source: org_study_id

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