RCT Ventralex vs Onlay Mesh in Incisional Hernias

NCT ID: NCT04358159

Last Updated: 2025-08-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

200 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-01-01

Study Completion Date

2027-09-30

Brief Summary

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A radomised controlled trial comparing Ventralex patch and Progrip mesh in surgery for midline incisional hernias

Detailed Description

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Incisional hernias in the midline is among the most common conditions requiring surgery. There are several factors which can increase the risk of incisional hernias, e.g. surgical technique, truncal obesity and other co-morbidities.

Repair with mesh-reinforcement is considered standard for the treatment of incisional hernias. Onlay and sublay mesh placements are the most commonly used methods. There are many different types of mesh available to use. Despite the widely use of composite ventral-patch Ventralex, there are few studies with small numbers of patients showing the advantage and disadvantage of ventral-patch. Some studies show that the onlay mesh-reinforcement remains a good alternative to the sublay mesh technique, while others showing fewer recurrences with the sublay mesh technique. The Ventralex mesh is usually placed on the peritoneum as a Intra peritoneum onlay mesh (IPOM). In this study intend to compare pre peritoneal Ventralex® mesh in sublay position with ProGrip self-fixating onlay mesh.

Conditions

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Incisional Hernia of Midline of Abdomen

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Randomised controlled trial of Vantralex versus Progrip for repair of midline incisional hernias
Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors
The patient and staff responsible for the postoperative care of the patient are masked to the acollcation.

Study Groups

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Ventralex

Repair with Ventralex patch in sublay position

Group Type EXPERIMENTAL

Ventralex

Intervention Type DEVICE

Repair of the hernia by a Ventralex patch in sublay position

Progrip

Repair with Progrip in Onlay position

Group Type ACTIVE_COMPARATOR

Progrip

Intervention Type DEVICE

Repair of the hernia by a Progrip mesh in onlay position

Interventions

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Ventralex

Repair of the hernia by a Ventralex patch in sublay position

Intervention Type DEVICE

Progrip

Repair of the hernia by a Progrip mesh in onlay position

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Hernia defect 1-4 cm
* Incisional hernia or recurrent hernia after previous primary hernia repair
* BMI \<35
* Age 18-100 years

Exclusion Criteria

* Defect size\>4 cm
* Ongoing pregnancy
* BMI\>35
* Primary hernia
Minimum Eligible Age

18 Years

Maximum Eligible Age

100 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Karolinska Institutet

OTHER

Sponsor Role lead

Responsible Party

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Gabriel Sandblom

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Gabriel Sandblom, MD

Role: PRINCIPAL_INVESTIGATOR

Karolinska Institutet

Locations

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Karlskoga Hospital

Karlskoga, , Sweden

Site Status NOT_YET_RECRUITING

Karlskoga Hospital

Karlskoga, , Sweden

Site Status RECRUITING

Countries

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Sweden

Central Contacts

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Gabriel Sandblom, MD, PhD

Role: CONTACT

+4686162362

Asmatullah Katawazai, MD

Role: CONTACT

+46586660 00

Facility Contacts

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Asmatullah Katawazai, MD

Role: primary

Asmatullah Katawazai, MD

Role: primary

Gabriel Sandblom, MD, PhD

Role: backup

Other Identifiers

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VPatchIncRCT

Identifier Type: -

Identifier Source: org_study_id

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