A Retrospective Cohort Study Outcome of Treatment in Asymptomatic Stage 4 Colorectal Cancer

NCT ID: NCT04334395

Last Updated: 2020-04-06

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 135 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2017-01-01
• Study Completion Date: 2020-03-31

Brief Summary

In asymptomatic Stage 4 colorectal cancer, the treatment varies between many hospitals and countries. Some studies found that primary tumor resection had better survival rates and a lower risk of mortality. But many studies found significant benefits in survival in sub groups of the population such as age less than 70 years, WHO performance status <2, no extra-hepatic metastasis, liver tumor burden <50%. However some studies showed no survival benefits in primary tumor resection. So this study will focus on survival, adverse events, complications in primary tumor resection and no primary tumor resection in asymptomatic Stage 4 colorectal cancer.

Detailed Description

The retrospective study of patients in asymptomatic Stage 4 colorectal cancer received treatment at Ramathibodi Hospital and excluded symptomatic primary tumors such as obstruction, perforation that required surgery, carcinomatosis peritoneii, and patients with secondary cancer diagnosis in the past 5 years.

Conditions

Stage IV Colon Cancer

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Interventions

primary tumor resection group

resection of cancer at colon

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

• Asymptomatic stage IV colorectal cancer
• pathological prove adenocarcinoma
• age >18 years
• no primary tumor related symptom
• ECOG performance status <2

Exclusion Criteria

• symptomatic primary tumor such as obstruction , perforation that required surgery
• carcinomatosis peritoneii
• patients with secondary cancer diagnosis in 5 years

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Mahidol University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Chairat Supsamutchai, MD

Role: STUDY_CHAIR

270, Rama VI road, Ratchathevi, Deapartment of Surgery, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand, 10400

Locations

Chairat Supsamutchai

Bangkok, Bankok, Thailand

Countries

Thailand

Other Identifiers

MURA2016/546

Identifier Type: -

Identifier Source: org_study_id