Preserving Left Colonic Artery During Radical Resection of Rectal Cancer

NCT ID: NCT03776370

Last Updated: 2022-05-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-12-01

Study Completion Date

2022-01-01

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

To evaluate the feasibility and clinical significance of preserving left colonic artery in rectal cancer surgery.The investigators will focus on the effect of preserving left colonic artery during radical resection of rectal cancer on anastomotic leakage and oncology efficacy.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The investigators performed three-dimensional (3D) reconstruction to investigate the vascular anatomy, including the inferior mesenteric artery (IMA) and left colic artery (LCA),to help make pre-operative strategies of rectal cancer surgery.The investigators will preserving the left colonic artery during rectal cancer surgery and evaluate its feasibility and clinical significance.The investigators will focus on the effect of preserving left colonic artery during radical resection of rectal cancer on anastomotic leakage and oncology efficacy.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Postoperative Complications Proteinosis

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Preserve the left colonic artery

Preservation of left colonic artery in rectal cancer surgery.

Preserve the left colonic artery

Intervention Type PROCEDURE

Preservation of left colonic artery in rectal cancer surgery.

The left colonic artery is not preserved

The left colonic artery was dissected in rectal cancer surgery

The left colonic artery is not preserved

Intervention Type PROCEDURE

The left colonic artery was dissected in rectal cancer surgery.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Preserve the left colonic artery

Preservation of left colonic artery in rectal cancer surgery.

Intervention Type PROCEDURE

The left colonic artery is not preserved

The left colonic artery was dissected in rectal cancer surgery.

Intervention Type PROCEDURE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

1. Pathological biopsy confirmed adenocarcinoma of the rectum;
2. Preoperative assessment of tolerance to surgery without major organ dysfunction;
3. Patients must be able to understand and voluntarily sign written informed consent;
4. The surgical method is laparoscopic or robotic anterior rectal cancer resection.

Exclusion Criteria

1. The patient cannot tolerate the operation;
2. Refusal to sign informed consent;
3. Patients with distant metastasis of rectal cancer;
4. The surgical method was changed to miles or Hartman;
5. Unable to complete the follow - up
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Third Military Medical University

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Weidong Tong

Clinical Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Wei d tong, PhD

Role: PRINCIPAL_INVESTIGATOR

Army Military Medical University

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

zongming,Kang

Chongqing, Chongqing Municipality, China

Site Status

zongming,Kang

Yuzhong, Chongqing Municipality, China

Site Status

Countries

Review the countries where the study has at least one active or historical site.

China

References

Explore related publications, articles, or registry entries linked to this study.

Fan YC, Ning FL, Zhang CD, Dai DQ. Preservation versus non-preservation of left colic artery in sigmoid and rectal cancer surgery: A meta-analysis. Int J Surg. 2018 Apr;52:269-277. doi: 10.1016/j.ijsu.2018.02.054. Epub 2018 Mar 1.

Reference Type RESULT
PMID: 29501795 (View on PubMed)

Sekimoto M, Takemasa I, Mizushima T, Ikeda M, Yamamoto H, Doki Y, Mori M. Laparoscopic lymph node dissection around the inferior mesenteric artery with preservation of the left colic artery. Surg Endosc. 2011 Mar;25(3):861-6. doi: 10.1007/s00464-010-1284-7. Epub 2010 Aug 20.

Reference Type RESULT
PMID: 20725744 (View on PubMed)

Zheng H, Li F, Xie X, Zhao S, Huang B, Tong W. Preservation versus nonpreservation of the left colic artery in anterior resection for rectal cancer: a propensity score-matched analysis. BMC Surg. 2022 May 10;22(1):164. doi: 10.1186/s12893-022-01614-y.

Reference Type DERIVED
PMID: 35538516 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

20181155

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.