A Translational Study for Locoregional Recurrence of T4 Colon Cancer
NCT ID: NCT06958926
Last Updated: 2025-05-25
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
60 participants
OBSERVATIONAL
2025-05-14
2028-12-31
Brief Summary
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The investigators hypothesize that peritoneal spreading can be one of the metastatic routes of T4 colon cancer; however, few studies have addressed the finding and deserved investigation. Previous research have found that serum epigenetic alterations and cell-free DNA can serve as a prognostic marker for stage II/III colon cancer.
Therefore, the aim of this study is (1) to explore the role of ascites cfDNA as a potential biomolecular marker for locoregional recurrence; (2) to identify the risk factors of locoregional recurrence for T4 colon cancer by correlating biomolecular markers between clinicopathology, epigenomic alterations in blood and ascites.
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Interventions
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Radical surgery for colon and rectum cancer
Radical surgery for colon and rectum cancer indicates that the surgery intends to eradicate all identifiable tumor in the human body.
Radical surgery for colorectal cancer
Radical surgery for colorectal cancer indicates that the surgery intends to eradicate all identifiable tumor in the human body.
Eligibility Criteria
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Inclusion Criteria
2. Diagnosed as colorectal cancer
3. Undergo radical colectomy or palliative colectomy, not limited to minimally invasive surgery or open surgery
Exclusion Criteria
2. Pregnancy
3. Patients with peritoneal dialysis
4. Patients who are unwilling to undergo colorectal surgery
18 Years
ALL
No
Sponsors
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National Taiwan University Hospital
OTHER
Responsible Party
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Principal Investigators
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Yu-Tso Liao, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
National Taiwan University Hospital Hsin-Chu Branch
Yu-Tso Liao
Role: PRINCIPAL_INVESTIGATOR
National Taiwan University Hospital Hsin-Chu Branch
Locations
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National Taiwan University Hospital Hsin-Chu branch
Hsinchu, , Taiwan
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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202407175RINC
Identifier Type: -
Identifier Source: org_study_id
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