Association of Copy Number Variations in the SMN Genes With Acute Kidney Injury After Heart Surgery

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

1206 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-04-01

Study Completion Date

2022-09-01

Brief Summary

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This prospective cohort study aims to explore the susceptibility to acute kidney injury after heart surgery in SMN1+/- genotype population. This study also aims to analysis the effect of SMN1+/- genotype on postoperative AKI and the development of chronic kidney disease, as well as dose-compensating effect of different copy number of SMN2 gene on SMN1 +/- genotype.

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Detailed Description

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This prospective cohort study aims to explore the susceptibility to acute kidney injury after heart surgery in SMN1+/- genotype population. Real-time PCR is used to detect copy number variations in the peripheral blood SMN gene on 1206 patients with heart surgery. This study also aims to analysis the effect of SMN1+/- genotype on postoperative AKI and the development of chronic kidney disease, as well as dose-compensating effect of different copy number of SMN2 gene on SMN1 +/- genotype.

Conditions

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Acute Kidney Injury

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Age: Children (1 month -17 years old) and adults (18-80 years old);
* Sex: All;
* Those who will receive selective cardiac surgery with cardiopulmonary bypass;
* Those who signed the informed consent.

Exclusion Criteria

* Those with glomerular filtration rate: eGFR\<15ml/min/1.73m2, and those who have received the renal replacement therapy before surgery;
* Those who have received nephrectomy and kidney transplantation;
* Those who have suffered from AKI before;
* Those with incomplete medical history or clinical data.

Minimum Eligible Age

1 Month

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No