Primary Sacroiliac Fusion Versus Fusion to the Sacrum for Degenerative Disease of the Lumbar Spine

NCT ID: NCT04308018

Last Updated: 2020-03-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

148 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-08-31

Study Completion Date

2023-08-31

Brief Summary

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To prove that the use of additional S2alar-iliac screws for pure lumbar fusions due to degenerative lumbar disease provides superior outcome compared to the standard procedure of fusion to S1.

Detailed Description

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Patients with symptomatic degenerative spine disease with or without spinal stenosis undergoing lumbosacral fusion to S1. Pedicle screws for posterior Instrumentation and fusion of the lumbar spine plus intervertebral fusion L5/S1 (anterior lumbar inter body fusion (ALIF), transforaminal lumbar inter body fusion (TLIF), or posterior lumbar inter body fusion (PLIF)) with

1. Caudal end of the instrumentation at S1
2. Caudal end of the instrumentation at iliac bone via S2alar-iliac screws

Stratification of both groups by:

* Number of instrumented levels
* Sagittal balance (Roussouly type 1+2 vs. 3+4)

Prospective, randomized, controlled, rater-blinded multicentric interventional study with two parallel groups

Conditions

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Degeneration Spine

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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S1

Caudal end of the instrumentation at S1

Group Type ACTIVE_COMPARATOR

S1 screws

Intervention Type PROCEDURE

Caudal end of the instrumentation at S1

S2alar-iliac

Caudal end of the instrumentation at iliac bone via S2alar-iliac screws

Group Type ACTIVE_COMPARATOR

S2alar-iliac screws

Intervention Type PROCEDURE

Caudal end of the instrumentation at iliac bone via S2alar-iliac screws

Interventions

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S2alar-iliac screws

Caudal end of the instrumentation at iliac bone via S2alar-iliac screws

Intervention Type PROCEDURE

S1 screws

Caudal end of the instrumentation at S1

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patients with symptomatic degenerative spine disease with or without spinal stenosis undergoing lumbosacral fusion to S1
* Lumbar or thoracolumbar Instrumentation
* Planned ventral intervertebral fusion (ALIF, TLIF, PLIF) in L5/S1
* Age ≥ 18 years

Exclusion Criteria

* Scoliosis \>20°
* Chronic steroid usage
* Significant co-morbidity influencing the surgical success:

* Osteoporosis
* Rheumatoid arthritis
* Mental illness/dementia
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Technical University of Munich

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Sandro Krieg, MD

Role: PRINCIPAL_INVESTIGATOR

Technical University Munich

Central Contacts

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Sandro Krieg, MD

Role: CONTACT

8941402151

Sebastian Ille, MD

Role: CONTACT

8941402151

Other Identifiers

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20/20

Identifier Type: -

Identifier Source: org_study_id

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