Metabolomics in Occupational Asthma

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

80 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-10-15

Study Completion Date

2023-06-01

Brief Summary

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The project aims to increase the diagnostic accuracy in occupational asthma (OA), with emphasis on Irritant Induced Asthma (IIA). Currently, most patients are evaluated in occupational medicine by comparing the exposure and symptom characteristics with epidemiological data. Biological markers may be present in AA, but presently not in IIA. The majority of cases evaluated are considered as possible IIA, i.e. low-dose multiple exposures. VOC features will be analyzed with the Breath Biopsy® and TD-GS-MS (Owlstone Medical Ltd, UK).

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Detailed Description

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Conditions

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Asthma, Occupational

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Occupational Asthma

Patients refered for assesment of occupational asthma

Breath Biopsy

Intervention Type DEVICE

ReCIVA breath sampler (Owlstone Medical, Cambridge, UK)

Respiratory Healthy Control

Employees at Oslo University Hospital

Breath Biopsy

Intervention Type DEVICE

ReCIVA breath sampler (Owlstone Medical, Cambridge, UK)

Interventions

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Breath Biopsy

ReCIVA breath sampler (Owlstone Medical, Cambridge, UK)

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* capable of informed consent.
* asthma diagnosis established by lung specialist or healthy control.

Exclusion Criteria

* skin allergy towards plastics or rubber.
* immunocompromised by oral medication.
* contagious respiratory disease.
* biopsy of lung parenchyma within the last 36 hours.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes