A Population-based Investigation of Asthma in the Telemark Region of Norway
NCT ID: NCT02073708
Last Updated: 2024-11-29
Study Results
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Basic Information
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ACTIVE_NOT_RECRUITING
2000 participants
OBSERVATIONAL
2018-02-01
2035-12-31
Brief Summary
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For Norway, there are no estimates of asthma prevalence for the country as a whole, but 80/1000 women and 55/1000 men used asthma medication in 2013 according to the national prescription register. Estimated annual deaths in Norway due to COPD were 4070 in 2015, which is 30% higher than for lung cancer. Unfortunately, a substantial proportion of patients are still difficult to treat. This underlines the need for better primary prevention and more knowledge regarding causes and exacerbating factors.
Several risk factors for chronic respiratory diseases are identified, most important tobacco smoke, closely followed by air pollution and occupational exposure. However, according to recent reviews there is a lack of understanding regarding environmental risk factors and mechanisms of how these affect respiratory health, the importance of biological markers and comorbidity, and of socioeconomic risk factors. Moreover, there is a need for assessment of interactions between risk factors and between the individual and the environment.
Telemark has a high proportion of craft- and industrial workers providing exposure contrasts. Furthermore, the use of medication against respiratory diseases and the rate of sick leave are higher in Telemark than elsewhere in Norway. Moreover, the county has a high rate of disability. There are previous studies from other parts of Norway, which have estimated the occurrence of respiratory diseases and provided valuable knowledge regarding some risk factors. However, these studies use crude measures of self-reported exposure and do not provide sufficient information on how to target intervention and implement effective prevention. In contrast to the Telemark study, these studies have not included register data or advanced modelling of environmental exposure.
Detailed Description
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Primary objective:
To identify preventive and health promoting measures for obstructive respiratory disease in a 5-year follow up of adults from the general population in Telemark.
Secondary objectives:
* Identify occupational risk factors for obstructive respiratory disease
* Assess interactions between risk factors and the individual
* Transfer relevant knowledge and advice regarding preventive and health promoting measures to individuals, health care professionals and authorities.
Research problems/questions (Q):
Q1 What are the emerging occupational risk factors for respiratory health? Q2 What are the social inequity/socioeconomic factors predicting respiratory disease? Q3 How does HRQoL develop over time? Q4 Do risk factors interact and how do they relate to the individual? Q5 What is the population attributable risk (PAR) for the identified risk factors, and what are the key factors for better prevention and respiratory health promotion?
Choice of methods/work packages (WP) and approaches (A):
WP I Occupational risk factors Q1 Emerging occupational causes and risk factors for respiratory disease and exacerbation
* A1.1 Assess associations between self-report of occupational exposure and new-onset and exacerbation of respiratory symptoms and diseases
* A1.2 Assess associations between job-exposure-matrix data (JEM) and new-onset and exacerbation of respiratory symptoms and diseases
WP II Individual risk factors Q2 Risk factors for social inequity in respiratory health
• A2.1 Assessment of the association between socio-demographic variables (gender, age, education, occupation and income) and respiratory health
WP III Complex interactions Q3 Health related quality of life development over time.
* A3.1 Impact of respiratory health and disease development and treatment on HRQoL development Q4 Interactions between risk factors and the individual
* A4.1 Identify interactions between risk factors and the individual by using advanced mathematical modelling Q5 The population attributable risk (PAR) for identified risk factors and key factors for better prevention and respiratory health promotion
* A5.1 Calculate PAR for risk factors identified in WP1-3 separately and combined
* A5.2 Based on PAR, estimate key factors for prevention and their cost
Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
* Controls without physician-diagnosed asthma
Exclusion Criteria
16 Years
50 Years
ALL
No
Sponsors
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Oslo University Hospital
OTHER
National Institute for Occupational Safety and Health (NIOSH/CDC)
FED
Göteborg University
OTHER
Sykehuset Telemark
OTHER_GOV
Responsible Party
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Anne Kristin M. Fell
MD, PhD
Principal Investigators
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Johny Kongerud, Professor
Role: STUDY_DIRECTOR
Oslo University, Oslo University Hospital
Anne Kristin Møller Fell, PhD
Role: PRINCIPAL_INVESTIGATOR
Sykehuset Telemark
Locations
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Telemark Hospital, dep. of Occupational and Environmental Medicine
Skien, Telemark, Norway
Countries
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References
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Lillienberg L, Andersson E, Janson C, Dahlman-Hoglund A, Forsberg B, Holm M, Glslason T, Jogi R, Omenaas E, Schlunssen V, Sigsgaard T, Svanes C, Toren K. Occupational exposure and new-onset asthma in a population-based study in Northern Europe (RHINE). Ann Occup Hyg. 2013 May;57(4):482-92. doi: 10.1093/annhyg/mes083. Epub 2012 Dec 1.
de Vocht F, Zock JP, Kromhout H, Sunyer J, Anto JM, Burney P, Kogevinas M. Comparison of self-reported occupational exposure with a job exposure matrix in an international community-based study on asthma. Am J Ind Med. 2005 May;47(5):434-42. doi: 10.1002/ajim.20154.
Delclos GL, Gimeno D, Arif AA, Benavides FG, Zock JP. Occupational exposures and asthma in health-care workers: comparison of self-reports with a workplace-specific job exposure matrix. Am J Epidemiol. 2009 Mar 1;169(5):581-7. doi: 10.1093/aje/kwn387. Epub 2009 Jan 6.
Fell AKM, Svendsen MV, Kim JL, Abrahamsen R, Henneberger PK, Toren K, Blanc PD, Kongerud J. Exposure to second-hand tobacco smoke and respiratory symptoms in non-smoking adults: cross-sectional data from the general population of Telemark, Norway. BMC Public Health. 2018 Jul 6;18(1):843. doi: 10.1186/s12889-018-5771-4.
Other Identifiers
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1665
Identifier Type: -
Identifier Source: org_study_id