Hearing Impairment as a Risk Factor for Dementia in Older Adults

NCT ID: NCT04284384

Last Updated: 2021-09-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

6952 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-08-19

Study Completion Date

2020-11-20

Brief Summary

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This Doctor of Philosophy (PhD) project is part of a larger project on potentially modifiable risk factors for dementia in a life course perspective, with an overarching aim to improve prevention of dementia and thereby potentially relieve patient and caregiver distress and decrease societal load. The present PhD project will concentrate on confirming knowledge of HI as an independent risk factor for dementia and exploring potentially causative factors to explain this relationship.

Detailed Description

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Despite a huge increase in the knowledge about disease mechanisms in various types of dementia in recent years, no curative treatment exists at present. Results from research on disease-modifying agents have been disappointing. This has led to an increased interest in other ways to reduce the prevalence of dementia. A recent report estimated that up to one third of dementia cases could be delayed or prevented by interventions directed at the most common risk factors. In the "Lancet commission on dementia prevention, treatment, and care", hearing impairment (HI) was identified as the potentially most important modifiable risk factor. Even though HI is considered an important modifiable risk factor, the evidence regarding the association between HI and dementia risk is still limited.

Conditions

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Dementia Hearing Loss

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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HUNT4 70+

All inhabitants of Nord-Trøndelag 70 years of age or older were invited to participate in HUNT4 70+.

No interventions assigned to this group

HUNT Trondheim 70+

All inhabitants of one district in Trondheim 70 years of age or older were invited to participate in HUNT4 70+.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Living in designated area

Exclusion Criteria

* None
Minimum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Norwegian University of Science and Technology

OTHER

Sponsor Role collaborator

The Nord-Trøndelag Health Study

UNKNOWN

Sponsor Role collaborator

The Norwegian Institute of Public Health

UNKNOWN

Sponsor Role collaborator

University College London Hospitals

OTHER

Sponsor Role collaborator

University of Oslo

OTHER

Sponsor Role collaborator

Norwegian Centre for Ageing and Health

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Geir Selbæk, PhD

Role: PRINCIPAL_INVESTIGATOR

Norwegian Centre for Ageing and Health

Locations

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Norwegian National Advisory Unit of Ageing and Health

Tønsberg, , Norway

Site Status

Countries

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Norway

References

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GjOra L, Strand BH, Bergh S, Borza T, Braekhus A, Engedal K, Johannessen A, Kvello-Alme M, Krokstad S, Livingston G, Matthews FE, Myrstad C, Skjellegrind H, Thingstad P, Aakhus E, Aam S, Selbaek G. Current and Future Prevalence Estimates of Mild Cognitive Impairment, Dementia, and Its Subtypes in a Population-Based Sample of People 70 Years and Older in Norway: The HUNT Study. J Alzheimers Dis. 2021;79(3):1213-1226. doi: 10.3233/JAD-201275.

Reference Type BACKGROUND
PMID: 33427745 (View on PubMed)

Myrstad C, Engdahl BL, Costafreda SG, Krokstad S, Livingston G, Selbaek G. Hearing and cognitive scores measured with the Montreal Cognitive Assessment Scale in The HUNT Study, Norway. Alzheimers Dement. 2025 Feb;21(2):e14514. doi: 10.1002/alz.14514. Epub 2025 Jan 23.

Reference Type DERIVED
PMID: 39846386 (View on PubMed)

Myrstad C, Engdahl BL, Costafreda SG, Krokstad S, Lin F, Livingston G, Strand BH, Ohre B, Selbaek G. Hearing impairment and risk of dementia in The HUNT Study (HUNT4 70+): a Norwegian cohort study. EClinicalMedicine. 2023 Dec 4;66:102319. doi: 10.1016/j.eclinm.2023.102319. eCollection 2023 Dec.

Reference Type DERIVED
PMID: 38192588 (View on PubMed)

Provided Documents

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Document Type: Statistical Analysis Plan

View Document

Other Identifiers

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181009

Identifier Type: -

Identifier Source: org_study_id

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