Acute Intermittent Hypoxia in Persons With Multiple Sclerosis
NCT ID: NCT04280484
Last Updated: 2020-02-24
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
10 participants
INTERVENTIONAL
2018-06-18
2019-12-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
DOUBLE
Study Groups
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Acute Intermittent Hypoxia
1 minute of 9% oxygen in the inspired air, alternating with 1 minute of 21% oxygen; for a total of 15 bouts
Intermittent Hypoxia
1 minute of 9% oxygen in the inspired air, alternating with 1 minute of 21% oxygen; for a total of 15 iterations/episodes.
Sham Acute Intermittent Hypoxia
1 minute of 21% oxygen in the inspired air, alternating with 1 minute of 21% oxygen; for a total of 15 bouts.
Sham Hypoxia
1 minute of 21% oxygen in the inspired air, alternating with 1 minute of 21% oxygen; for a total of 15 iterations/episodes.
Interventions
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Intermittent Hypoxia
1 minute of 9% oxygen in the inspired air, alternating with 1 minute of 21% oxygen; for a total of 15 iterations/episodes.
Sham Hypoxia
1 minute of 21% oxygen in the inspired air, alternating with 1 minute of 21% oxygen; for a total of 15 iterations/episodes.
Eligibility Criteria
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Inclusion Criteria
* Volitional ankle plantar flexion strength in at least one leg
* Are relapse free for 30 days
* Patient-Determined Disease Steps scale score between 3 and 5 (3=gait disability to 5=late cane, need cane to walk 25 feet)
Exclusion Criteria
* Have cardiovascular or respiratory/pulmonary disorders, metabolic dysfunction, or prior diagnoses of obstructive sleep apnea
* Pregnant or nursing women (safety for developing fetus or infant is unknown)
* Cognitive concerns (must be able to consent to study, follow steps)
18 Years
75 Years
ALL
No
Sponsors
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Edward Hines Jr. VA Hospital
FED
Shirley Ryan AbilityLab
OTHER
Responsible Party
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Milap Sandhu
Principal Investigator
Locations
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Shirley Ryan AbilityLab
Chicago, Illinois, United States
Countries
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Other Identifiers
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STU00207024
Identifier Type: -
Identifier Source: org_study_id
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