Normobaric Hypoxic Training and Multiple Sclerosis

NCT ID: NCT02509897

Last Updated: 2022-07-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

39 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-07-31

Study Completion Date

2018-07-31

Brief Summary

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To study the effects of normobaric hypoxic training on cardiorespiratory fitness, resting, postprandial and exercise activity energy expenditure, immunoregulatory functions and serum erythropoietin levels in relapsing-remitting multiple sclerosis patients.

Detailed Description

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Conditions

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Multiple Sclerosis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Study Groups

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Hypoxic training

Endurance training

Group Type ACTIVE_COMPARATOR

Hypoxic training

Intervention Type OTHER

Hypoxic training 3 times per week four four weeks

Normoxic training

Endurance training

Group Type PLACEBO_COMPARATOR

Normoxic training

Intervention Type OTHER

Normoxic training 3 times per week four four weeks

Interventions

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Hypoxic training

Hypoxic training 3 times per week four four weeks

Intervention Type OTHER

Normoxic training

Normoxic training 3 times per week four four weeks

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* stable immunomodulatory therapy
* expanded disability status scale score \< 4.5
* body mass index 18.5 - 29.9 kg/m2

Exclusion Criteria

* clinically relevant heart, lung, liver, and kidney diseases
Minimum Eligible Age

20 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Charite University, Berlin, Germany

OTHER

Sponsor Role lead

Responsible Party

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Anja Maehler

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Friedemann Paul, Prof.

Role: PRINCIPAL_INVESTIGATOR

Charite University, Berlin, Germany

Locations

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Experimental & Clinical Research Center

Berlin, , Germany

Site Status

Countries

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Germany

References

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Mahler A, Balogh A, Csizmadia I, Klug L, Kleinewietfeld M, Steiniger J, Susnjar U, Muller DN, Boschmann M, Paul F. Metabolic, Mental and Immunological Effects of Normoxic and Hypoxic Training in Multiple Sclerosis Patients: A Pilot Study. Front Immunol. 2018 Nov 29;9:2819. doi: 10.3389/fimmu.2018.02819. eCollection 2018.

Reference Type RESULT
PMID: 30555484 (View on PubMed)

Related Links

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Other Identifiers

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EpoxiMet

Identifier Type: -

Identifier Source: org_study_id

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