Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
35 participants
INTERVENTIONAL
2012-02-29
2014-01-31
Brief Summary
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Detailed Description
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Previous studies have reported positive effects of PRT on muscle strength, functional capacity, fatigue and quality of life. Also, a possible disease modifying effect has been proposed. However, the underlying physiological mechanisms that might explain these beneficial effects and the possible effects on disease progression are unresolved. Additionally, none of the previous studies has been concerned with the possible impact of MS progression type, gender and/or medication.
The purpose of this randomized, controlled, gender stratified trial is to investigate underlying mechanisms possibly explaining the beneficial effects of progressive resistance training for people with multiple sclerosis.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Training
Training
Bi-weekly progressive resistance training
Control
No interventions assigned to this group
Interventions
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Training
Bi-weekly progressive resistance training
Eligibility Criteria
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Inclusion Criteria
* Expanded Disability Status Scale (EDSS) between 2.0 and 5.5
* Be able to train twice a week at the University
* Use interferon based medication
Exclusion Criteria
* Comorbidities like cardiovascular-, respiratory-, orthopaedic or metabolic diseases
* Having had an attack in a period of 8 weeks prior to the start of the intervention period
* Having an attack during the intervention period
* Pregnancy
* Systematic resistance training in a period of 3 months prior to the start of the intervention period.
* Training adherence of less than 85%.
18 Years
60 Years
ALL
No
Sponsors
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Aarhus University Hospital
OTHER
Biogen
INDUSTRY
University of Aarhus
OTHER
Responsible Party
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Principal Investigators
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Tue Kjølhede, M.Sc.
Role: PRINCIPAL_INVESTIGATOR
Sport Science, Department of Public Health, Aarhus University
Ulrik Dalgas, Ph.D.
Role: STUDY_CHAIR
Sport Science, Department of Public Health, Aarhus University
Kristian Vissing, Ph.D.
Role: STUDY_CHAIR
Sport Science, Department of Public Health, Aarhus University
Thor Petersen, Dr.med
Role: STUDY_CHAIR
MS Clinic, Department of Neurology, Aarhus University Hospital
Locations
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MS Clinic, Department of Neurology, Aarhus University Hospital
Aarhus C, , Denmark
Sport Science, Aarhus University
Aarhus C, , Denmark
Countries
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Other Identifiers
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MS&PRT_SSAU_TK
Identifier Type: -
Identifier Source: org_study_id