Acute Effects of Whole-body Vibration Training in Hypoxia and Normoxia in Multiple Sclerosis Patients

NCT ID: NCT03856801

Last Updated: 2019-02-27

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 13 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2018-06-15
• Study Completion Date: 2018-08-30

Brief Summary

Multiple Sclerosis (ME) is a degenerative, inflammatory and autoimmune demyelinating disease of the central nervous system, characterized by demyelination due to inflammation and degeneration of the myelin sheaths enveloping nerves of the eye, periventricular grey matter, brain, spinal cord and brainstem. The symptoms associated with MS include symptomatic fatigue, muscle weakness, ataxia, mobility and balance problems or cognitive problems. Moderate intensity strength training has been shown to improve strength and mobility in persons with MS. It was suggested that whole-body vibration training (WBVT) is effective to improve muscle strength, such as resistance training, resulting from both neural and structural adaptations. On the other hand, traditional strength training in hypoxia has garnered much attention. This method has shown improvements in isometric strength and increases in muscle size.

Detailed Description

• Crossover.
• 13 patients with multiple sclerosis were recruited.
• Patients performed two sessions: whole-body vibration training in normoxia condition and whole-body vibration in hypoxia condition.

Conditions

Multiple Sclerosis

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: SUPPORTIVE_CARE
• Blinding Strategy: SINGLE

Study Groups

Whole-body vibration in normoxia condition

Training session in normoxia condition

Group Type: EXPERIMENTAL

Exercise

Intervention Type: OTHER

Whole-body vibration training in hypoxia and normoxia condition

Whole-body vibration in hypoxia condition

Training session in hypoxia condition

Group Type: EXPERIMENTAL

Exercise

Intervention Type: OTHER

Whole-body vibration training in hypoxia and normoxia condition

Interventions

Exercise

Whole-body vibration training in hypoxia and normoxia condition

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• mild or moderate disability with clinical mild spastic-ataxic gait disorder.
• stable phase of the disease.

Exclusion Criteria

• Expanded Disability Status Scale (EDSS) < 6.
• relapsing disease within the preceding 12 months.
• corticosteroid treatment within the last months before study inclusion.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Universidad Católica San Antonio de Murcia

OTHER

Sponsor Role: lead

Responsible Party

Jacobo Á. Rubio

Profesor Titular

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Universidad Católica San Antonio

Murcia, , Spain

Countries

Spain

Other Identifiers

CE061908

Identifier Type: -

Identifier Source: org_study_id