ACTH Stability on Whole Blood

NCT ID: NCT04266587

Last Updated: 2020-06-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-07-31

Study Completion Date

2020-11-30

Brief Summary

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ACTH is a peptide secreted by pituitary gland and plays an important role in regulating cortisol secretion. ACTH is determined in plasma by immunoassays using specific antibodies. Its determination is difficult because of instability in whole blood. Several factors which influence ACTH stability in blood before analysis have been identified: temperature, hemolysis, time to centrifugation and presence of protease inhibitors. Published results on ACTH whole blood stability seem contradictory.

The objective of this study is to evaluate the effect of aprotinin in 10 healthy volunteers. ACTH measurements will be performed on cobas e602 (Roche Diagnostics, Mannheim, Germany).

Detailed Description

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Conditions

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ACTH

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Healthy volunteers

blood sampling is done on healthy volunteers

Group Type EXPERIMENTAL

Blood sampling

Intervention Type BIOLOGICAL

blood sampling is done on healthy volunteers

Interventions

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Blood sampling

blood sampling is done on healthy volunteers

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* Adult patient aged 18 to 60,

Exclusion Criteria

* Adult with insufficient venous capital for blood collection
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University Hospital, Rouen

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Francois FRAISSINET

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Rouen

Locations

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Rouen University Hospital

Rouen, , France

Site Status

Countries

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France

Central Contacts

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Francois FRAISSINET

Role: CONTACT

+3323288 ext. 5866

Julien BLOT

Role: CONTACT

+3323288 ext. 8265

Facility Contacts

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Francois FRAISSINET

Role: primary

Other Identifiers

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2019/0350/HP

Identifier Type: -

Identifier Source: org_study_id

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