Accelerometer Sensing for Micra AV Study

NCT ID: NCT04245345

Last Updated: 2023-02-23

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

157 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-06-09

Study Completion Date

2022-01-10

Brief Summary

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The purpose of the AccelAV Study is to characterize chronic AV synchrony in subjects implanted with MicraTM AV device. This study will be conducted upon market approval of the MicraTM AV Transcatheter Pacing System.

Detailed Description

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The Accel AV study is a prospective, single-arm, global, multi-center clinical study to characterize the chronic AV synchrony in subjects implanted with the market released Micra AV system. The study is planned to be conducted in the US and Hong Kong. Overall, the study is expected to be conducted at approximately 20 centers.The expected total study duration is approximately 12-15 months, representing the time necessary to enroll the target sample size and to complete the 3-month follow-up visit.

Conditions

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AV Block AV Block Complete 3rd Degree Heart Block Complete Heart Block

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Single-arm

Subjects implanted with the Medtronic Micra AV device

Group Type OTHER

Accelerometer Sensing for Micra AV Study

Intervention Type DEVICE

Characterize AV synchrony in subjects implanted with Micra AV device. The study will be conducted upon market approval of the Micra AV Transcatheter Pacing System.

Interventions

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Accelerometer Sensing for Micra AV Study

Characterize AV synchrony in subjects implanted with Micra AV device. The study will be conducted upon market approval of the Micra AV Transcatheter Pacing System.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

Subject will be implanted with a MicraTM (Model MC1AVR1) for an approved indication.

* Subject has history of AV block.
* Subject is ≥ 18 years old and as per required local law.
* Subject (and/or witness as applicable per local regulations) provides signed and dated authorization and/or consent per institution and local requirements.
* Subject is willing and able to comply with the protocol.

Exclusion Criteria

* Subject currently enrolled or planning to participate in a potentially confounding drug or device trial during the study. Co-enrollment in concurrent trials is only allowed when documented pre-approval is obtained from the Medtronic Clinical Research Specialist.
* Subject implanted with a MicraTM (Model MC1AVR1) on a non-permanent basis (e.g. CIED infection).
* Subject is pregnant (if required by local law, women of child-bearing potential must undergo a pregnancy test within seven days prior to MicraTM Model MC1AVR1 implant procedures).
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Medtronic Cardiac Rhythm and Heart Failure

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Larry Chinitz, MD

Role: STUDY_CHAIR

NYU Langone

Locations

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Saint Joseph's Medical Center

Stockton, California, United States

Site Status

Baptist Medical Center Jacksonville

Jacksonville, Florida, United States

Site Status

Citrus Cardiology Consultants PA

Leesburg, Florida, United States

Site Status

Emory University Hospital

Atlanta, Georgia, United States

Site Status

Catholic Medical Center

Manchester, New Hampshire, United States

Site Status

Northwell Health

Manhasset, New York, United States

Site Status

NYU Langone Medical Center

New York, New York, United States

Site Status

Duke University Nedical Center

Durham, North Carolina, United States

Site Status

Wake Forest Baptist Medical Center

Winston-Salem, North Carolina, United States

Site Status

University Hospitals Cleveland Medical Center

Cleveland, Ohio, United States

Site Status

The Ohio State University Wexner Medical Center

Columbus, Ohio, United States

Site Status

Mount Carmel Health System

Columbus, Ohio, United States

Site Status

Oregon Health & Science University

Portland, Oregon, United States

Site Status

Thomas Jefferson University

Philadelphia, Pennsylvania, United States

Site Status

Centennial Heart Cardiovascular Consultants

Nashville, Tennessee, United States

Site Status

Baylor Research Institute

Plano, Texas, United States

Site Status

Multicare Institute for Research and Innovation

Tacoma, Washington, United States

Site Status

University of Wisconsin (UW) Hospital and Clinics

Madison, Wisconsin, United States

Site Status

Queen Mary Hospital

Hong Kong, HK, Hong Kong

Site Status

Prince of Wales Hospital

Shatin, HK, Hong Kong

Site Status

Countries

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United States Hong Kong

References

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Chinitz LA, El-Chami MF, Sagi V, Garcia H, Hackett FK, Leal M, Whalen P, Henrikson CA, Greenspon AJ, Sheldon T, Stromberg K, Wood N, Fagan DH, Sun Chan JY. Ambulatory atrioventricular synchronous pacing over time using a leadless ventricular pacemaker: Primary results from the AccelAV study. Heart Rhythm. 2023 Jan;20(1):46-54. doi: 10.1016/j.hrthm.2022.08.033. Epub 2022 Sep 6.

Reference Type DERIVED
PMID: 36075532 (View on PubMed)

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

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AccelAV

Identifier Type: -

Identifier Source: org_study_id

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